{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:12Z","timestamp":1790546172936,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204764"],"award-info":[{"award-number":["82204764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274212"],"award-info":[{"award-number":["82274212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Wuwei Leze Powder (WLP, \u0f66\u0fb3\u0fb1\u0f7a\u0f0b\u0f4f\u0fb1\u0f7a\u0f66\u0f63\u0f94\u0f0b\u0f50\u0f44\u0f0d) is a classic Tibetan medicine formula with clinical efficacy against rheumatoid arthritis (RA), but its in vivo pharmacokinetic (PK) behavior is unclear. This study aimed to elucidate the absorption, metabolism, pharmacokinetics, and tissue distribution of WLP in rats. UPLC\u2010Q\u2010TOF\u2010MS and UPLC\u2010QQQ\u2010MS were used to qualitatively and quantitatively analyze WLP components in rat plasma and tissues. Fifty\u2010six plasma constituents (21 prototypes, 35 metabolites) were identified. Nine compounds\u2014syringin, cordifolioside A, sweroside, mangiferin, norswertianolin, isovitexin, ellagic acid, amarogentin, and arjungenin\u2014were quantified. All were detectable in plasma within 15\u00a0min, with peak concentrations at 0.75\u20132\u00a0h ellagic acid and mangiferin showed the highest systemic exposure (\n                    <jats:italic>AUC<\/jats:italic>\n                    <jats:sub>0\u2192t<\/jats:sub>\n                    : 5007.26 and 3354.21 \u00b5g\/L\u00b7h;\n                    <jats:italic>\n                      C\n                      <jats:sub>max<\/jats:sub>\n                    <\/jats:italic>\n                    : 1491.27 and 749.00 \u00b5g\/L). Half\u2010lives ranged from 2.63 to 5.26\u00a0h. All nine compounds distributed to all tested tissues within 0.5\u00a0h, with residues significantly decreased by 8\u00a0h and no accumulation observed. The nine compounds are rapidly absorbed and broadly distributed, particularly to synovium, liver, and kidney. Amarogentin, mangiferin, ellagic acid, cordifolioside A, and arjungenin are identified as primary in vivo exposed compounds, supporting the potential pharmacodynamic material basis of WLP against RA.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71653","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:35:19Z","timestamp":1788201319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetics and Tissue Distribution in Rats After Oral Administration of Tibetan Medicine Wuwei Leze Powder"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9910-8443","authenticated-orcid":false,"given":"Ping","family":"Wang","sequence":"first","affiliation":[{"name":"School of Food and Bio\u2010engineering Xihua University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Food and Bio\u2010engineering Xihua University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiRui","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Food and Bio\u2010engineering Xihua University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8739-8209","authenticated-orcid":false,"given":"ShuiYing","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Food and Bio\u2010engineering Xihua University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2541-1630","authenticated-orcid":false,"given":"HuiJuan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Food and Bio\u2010engineering Xihua University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3380-5310","authenticated-orcid":false,"given":"WenYu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Food and Bio\u2010engineering Xihua University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8944-4174","authenticated-orcid":false,"given":"Ya","family":"Tu","sequence":"additional","affiliation":[{"name":"Experimental Research Center China Academy of Chinese Medicine Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-8949","authenticated-orcid":false,"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food and Bio\u2010engineering Xihua University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Y.Yutuo The Four Medical Tantras \u00a0Tibet People's Publishing House Lasa 1982."},{"key":"e_1_2_11_3_1","volume-title":"Drug standards of the ministry of health of the People's Republic of China","author":"Ministry of Health of the People's Republic of China","year":"1995"},{"key":"e_1_2_11_4_1","first-page":"2883","article-title":"Thinking About Research on Medicinal Materials and Decoction Pieces Used in Traditional Chinese Medicine Compound Preparations Developed From Catalogued Ancient Classical Prescriptions","volume":"50","author":"Liu S. 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