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HN\u201017. Their structures were elucidated using comprehensive spectroscopic methods, including 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    showed significant anti\u2010inflammatory activity with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 10.2 and 13.5\u00a0\u00b5M, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71654","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:22:51Z","timestamp":1788524571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two\n                    <i>\u03b3<\/i>\n                    \u2010Lactone Derivatives With Anti\u2010Inflammatory Activities From a Mangrove Endophytic Fungus\n                    <i>Alternaria<\/i>\n                    sp. HN\u201017"],"prefix":"10.1002","volume":"23","author":[{"given":"Yuru","family":"Sun","sequence":"first","affiliation":[{"name":"School of Pharmacy Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxue","family":"Mu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqian","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxuan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-4072","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi5200"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(24)60601-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2025.2563522"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108752"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113179"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00041A"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114117"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/md23120474"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules31020261"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108898"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2005.08.018"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-018-2390-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.200610260"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.57.863"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5c00357"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QO01917A"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(23)60446-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/np800127b"},{"key":"e_1_2_9_21_1","first-page":"2745","article-title":"Synthesis and Antifungal Activity of Aromatic Bis\u2010Gamma\u2010Lactones Analogous to Avenaciolide","volume":"35","author":"Castelo\u2010Branco P. 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