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In antidiabetic assays, the nanocomposite showed strong inhibitory effects on alpha\u2010amylase (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 21.57 \u00b1 1.68\u00a0mg\/mL) and alpha\u2010glucosidase (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 13.95 \u00b1 0.76\u00a0mg\/mL), with activities comparable to acarbose, while anti\u2010inflammatory tests yielded low IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.22 \u00b1 0.03\u00a0mg\/mL for egg albumin denaturation and 0.34 \u00b1 0.07\u00a0mg\/mL for human serum albumin, approaching the performance of diclofenac. Antioxidant performance was outstanding, with total antioxidant capacity of 298.27 \u00b1 4.70\u00a0mg ascorbic acid equivalents per gram and ferric reducing antioxidant power of 311.67 \u00b1 2.53\u00a0mM Fe\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \/g, both higher than ascorbic acid, alongside efficient hydrogen peroxide scavenging (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.16 \u00b1 0.04\u00a0mg\/mL) and protection against H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \/FeCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced hemolysis at an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 0.007 \u00b1 0.00\u00a0mg\/mL; together with moderate but significant acetylcholinesterase inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 33.16 \u00b1 3.02\u00a0mg\/mL vs. 21.80 \u00b1 2.74\u00a0mg\/mL for donepezil), these results support ZnO\/CuO@amoxicillin as a multifunctional nano\u2010platform for managing oxidative stress, inflammation, and metabolic disorders.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71658","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:29:22Z","timestamp":1788427762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Characterization, and Multifunctional Bioactivity of ZnO\/CuO@Amoxicillin Nanocomposites: A Synergistic Nano\u2010Platform With Potent Antioxidant, Anti\u2010Inflammatory, Antidiabetic, and Anti\u2010Cholinesterase Activities"],"prefix":"10.1002","volume":"23","author":[{"given":"Hocine Sadam","family":"Nesrat","sequence":"first","affiliation":[{"name":"Laboratory of Analysis, Treatment and Recovery of Environmental Pollutants and 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