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Y\u0131ld\u0131z &amp; H.\u0130. Turko\u011flu. Methanolic extracts from leaves, stems, and roots were characterized by LC\u2010MS\/MS, and their antioxidant, enzyme inhibitory, and antiproliferative activities were investigated. The analyses showed organ\u2010specific differences in phenolic composition, with quinic acid as the major compound in leaves together with higher levels of flavonoid glycosides, including astragalin and isoquercitrin. Aerial extracts showed strong enzyme inhibitory activity. Leaf and stem extracts exhibited cholinesterase inhibition, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.82 and 6.42\u00a0\u00b5g\/mL for AChE and 5.41 and 5.50\u00a0\u00b5g\/mL for BChE, respectively. The leaf extract showed\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase inhibitory activity (4.10\u00a0\u00b5g\/mL), comparable to acarbose, and antioxidant activity (DPPH: 6.46\u00a0\u00b5g\/mL), together with the highest phenolic (145.43\u00a0mg GAE\/g extract) and flavonoid contents (87.20\u00a0mg QE\/g extract). Antiproliferative assays demonstrated growth inhibition of lung and breast cancer cell lines, with the lowest GI\n                    <jats:sub>50<\/jats:sub>\n                    values of 1.00\u00a0\u00b5g\/mL for H1650 and 2.34\u00a0\u00b5g\/mL for MDA\u2010MB\u2010231 cells. LDH cytotoxicity remained low (2.25%\u201312.59%), indicating limited membrane damage in both cancer and normal cells. These findings identify\n                    <jats:italic>H. yilmazunalii<\/jats:italic>\n                    as a source of compounds with antioxidant, neuroprotective, antidiabetic, and anticancer potential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71659","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:16:37Z","timestamp":1788426997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First Report on the Phytochemical and Pharmacological Properties of\n                    <i>Hedysarum\u00a0yilmazunalii<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-8194","authenticated-orcid":false,"given":"Etem","family":"Osma","sequence":"first","affiliation":[{"name":"Department of Biology Faculty of Sciences and Arts Erzincan Binali Y\u0131ld\u0131r\u0131m University  Erzincan 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