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HPLC analysis identified rutin, isoquercitrin, and kaempferol\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010rutinoside as the major phenolic compounds. Both extracts exhibited low toxicity and no sedative effects at the lowest tested doses. ELM showed abdominal antinociceptive activity mediated by TRPA1 and significantly reduced carrageenan\u2010induced abdominal edema. EBM inhibited both corneal (TRPV1) and abdominal (TRPA1) nociception, producing effects similar to morphine. Molecular docking corroborated the in vivo findings, revealing favorable interactions with TRPA1, COX\u20102, and TRPV1, supported by stable hydrogen\u2010bond formation. The combined chemical, biological, and computational evidence highlights murici as a promising natural source of multifunctional phytotherapeutic agents with antinociceptive activity and potential anti\u2010inflammatory properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71661","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:14:33Z","timestamp":1789931673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Characterization and Pharmacological Activity of\n                    <i>Byrsonima crassifolia<\/i>\n                    (L.) Kunth (Murici): Antinociceptive Effects, Edema Reduction, and Molecular Docking"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5583-5193","authenticated-orcid":false,"given":"Lucas S.","family":"Frota","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biotechnology, Natural Products Chemistry Laboratory State University of Cear\u00e1  Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara I. C. G.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology, Natural Products Chemistry Laboratory State University of Cear\u00e1  Fortaleza CE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R. 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