{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:14Z","timestamp":1790546174760,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The peel of\n                    <jats:italic>Citrus hystrix<\/jats:italic>\n                    DC. (kaffir lime), an underexploited agro\u2010industrial by\u2010product, may have bioactives. This work tested the ethanolic extract of\n                    <jats:italic>C. hystrix<\/jats:italic>\n                    peel's (EeChP) phytochemicals by GC\u2010MS profiling, and the antidiabetic effect was evaluated using the alpha\u2010amylase inhibitory test, and the anti\u2010inflammatory activity was done using the human red blood cell (HRBC) membrane model. The antibacterial effect was determined using the agar well diffusion method against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    . Major constituents subjected to pharmacokinetic and ADMET filtering, molecular docking, Gene Ontology (GO), and KEGG pathway analysis for mechanistic plausibility. The GC\u2010MS detected 44 phytoconstituents, including limonene, \u03b3\u2010sitosterol, and \u03b2\u2010amyrin. EeChP inhibited \u03b1\u2010amylase (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 80.97 \u00b5g\/mL) and the stabilized HRBC membrane (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 64 \u00b5g\/mL). The extract demonstrated substantial antibacterial action against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (IZD = 6 mm at 200 \u00b5g\/well) but failed against\n                    <jats:italic>E. coli<\/jats:italic>\n                    . The \u03b2\u2010amyrin and scoparone were found to be non\u2010toxic. Scoparone and carbonic anhydrase 12 were connected with \u03b2\u2010amyrin and protein tyrosine phosphatase non\u2010receptor type 1. EeChP has anti\u2010diabetic, multi\u2010target, modulatory, and anti\u2010inflammatory effects. The results recommend\n                    <jats:italic>C. hystrix<\/jats:italic>\n                    peel's bioresource potential, but enzyme kinetics, antimicrobial MIC, and in vivo research are necessary. The research has contributed to accomplishing SDG 3 and SDG 12.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71665","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:35:58Z","timestamp":1789036558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combining Phytochemical and Computational Approach on\n                    <i>Citrus hystrix<\/i>\n                    DC. (Kaffir Lime) Peel Extract: Anti\u2010Diabetic and Anti\u2010Inflammatory Activities"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4753-4563","authenticated-orcid":false,"given":"Malathy","family":"Soundara Rajan","sequence":"first","affiliation":[{"name":"Dept of Bioinformatics, School of Bio and Chemical Engineering Sathyabama Institute of Science and Technology  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3737-9184","authenticated-orcid":false,"given":"Sankarganesh","family":"Palaniyandi","sequence":"additional","affiliation":[{"name":"Oculo\u2010Nutri Interdisciplinary Lab, Saveetha Medical College and Hospital Saveetha Institute of Medical and Technical Sciences (SIMATS)  Thandalam Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9103-5070","authenticated-orcid":false,"given":"Swetha","family":"Sunkar","sequence":"additional","affiliation":[{"name":"Dept of Bioinformatics, School of Bio and Chemical Engineering Sathyabama Institute of Science and Technology  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.24911\/IJMDC.51-1733905807"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755\u20101315\/1292\/1\/012018"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70027"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094\u2010024\u201000671\u20109"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.jpbs_591_23"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-45513-1.00007-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/1757\u2010899X\/1092\/1\/012082"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.70088"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.59796\/jcst.V13N3.2023.888"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.22146\/jtbb.66061"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.11002\/kjfp.2023.30.3.395"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113151"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28062596"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512410"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20104546\u20108_4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202403269"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab255"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci500588j"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm795"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010021\u201004438\u20104"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340080302"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.jpbs_585_23"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcdf.2014.06.001"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.21608\/zjar.2018.48589"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.143550"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.144570"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414\u2010431X2021e11391"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010022\u201001028\u20109"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijfs.16031"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2025.115900"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.09.027"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2021.58429.12977"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S330947"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2026.139601"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40816\u2010020\u201000207\u20107"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v13.i9.1164"},{"key":"e_1_2_12_39_1","first-page":"2467","article-title":"Assessment 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