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In this study, we report the design and synthesis of a new D\u2010glucamine\u2010based Schiff base containing a triazolyl silatrane probe (\n                    <jats:bold>6<\/jats:bold>\n                    ) and its Fe(II) and Cu(II) complexes, followed by investigation of their interactions with calf thymus DNA (CT\u2010DNA). The synthesized ligand and its metal complexes were characterized by elemental analysis, FT\u2010IR, UV\u2013vis spectroscopy, ESI\u2010MS, and NMR spectroscopy (\n                    <jats:sup>1<\/jats:sup>\n                    H and\n                    <jats:sup>13<\/jats:sup>\n                    C for the free ligand). DNA\u2010binding properties were evaluated by UV\u2013vis absorption spectroscopy, ethidium bromide (EtBr) displacement fluorescence assays, and molecular docking studies. The combined experimental and computational results indicate that ligand\n                    <jats:bold>6<\/jats:bold>\n                    interacts predominantly with CT\u2010DNA through groove binding, whereas complexation with Fe(II) or Cu(II) enhances DNA\u2010binding affinity and modulates the interaction toward a mixed groove\u2010binding\/intercalative mode. The higher binding constants, enhanced fluorescence quenching, and favorable docking interactions observed for the metal complexes support this metal\u2010induced modulation of DNA\u2010binding behavior. Overall, the findings demonstrate that metal complexation can tune both the strength and mode of DNA binding, highlighting a potential strategy for designing silatrane\u2010based metal complexes with DNA\u2010targeting applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71668","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:19:38Z","timestamp":1788427178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron(II) and Copper(II) Ions Modulating Binding Interaction of Sugar\u2010Based Silatrane With DNA: Analytical and Theoretical Validation"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-420X","authenticated-orcid":false,"given":"Gurjaspreet","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; Centre for Advanced Studies in Chemistry Panjab University  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9462-4193","authenticated-orcid":false,"family":"Pawan","sequence":"additional","affiliation":[{"name":"Department of Chemistry University School of Sciences Rayat\u2010Bahra University  Mohali India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-9152","authenticated-orcid":false,"given":"Brij","family":"Mohan","sequence":"additional","affiliation":[{"name":"Centro De Qu\u00edmica Estrutural Instituto Superior T\u00e9cnico Universidade De Lisboa (ULisboa)  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102629"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/b822719e"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2005.07.086"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2733"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500133"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.054"},{"key":"e_1_2_8_8_1","first-page":"241","article-title":"DNA\u2010Intercalating Ligands as Anti\u2010Cancer Drugs: Prospects for Future Design","volume":"4","author":"Denny W. 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