{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:57:53Z","timestamp":1790542673384,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177143"],"award-info":[{"award-number":["22177143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Deep\u2010sea\u2010derived fungi have emerged as a prolific source of structurally novel and pharmacologically active secondary metabolites, representing an invaluable reservoir of lead compounds for drug discovery and development. In the present study, one new tyramine derivative (\n                    <jats:bold>1<\/jats:bold>\n                    ) and 28 known compounds (\n                    <jats:bold>2\u201329<\/jats:bold>\n                    ) were obtained from\n                    <jats:italic>Talaromyces wortmannii<\/jats:italic>\n                    MCCC 3A01136, a fungus isolated from the intestinal contents of a stranded deep\u2010sea whale (\n                    <jats:italic>Mesoplodon densirostris<\/jats:italic>\n                    ) in the East China Sea. The structures were elucidated via comprehensive analysis of 1D and 2D NMR data, HRESIMS, NMR computations coupled with DP4+ probability analysis, and ECD calculations. Comazaphilones E (\n                    <jats:bold>2<\/jats:bold>\n                    ) and C (\n                    <jats:bold>6<\/jats:bold>\n                    ) significantly inhibited renin\u2010angiotensin system\u2010selective lethal 3 (RSL3)\u2010induced ferroptosis with a half maximal effective concentration (EC\n                    <jats:sub>50<\/jats:sub>\n                    ) value of 4.52 and 13.73 \u00b5M, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71678","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:20:27Z","timestamp":1789467627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Constituents of the Deep\u2010Sea\u2010Derived Fungus\n                    <i>Talaromyces wortmannii<\/i>\n                    and Their Ferroptosis Inhibitory Activity"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1898-5636","authenticated-orcid":false,"given":"Ke\u2010Xin","family":"Ma","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang China"},{"name":"Hainan Academy of Medical Sciences Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8824-7272","authenticated-orcid":false,"given":"Zheng\u2010Biao","family":"Zou","sequence":"additional","affiliation":[{"name":"Hainan Academy of Medical Sciences Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Qian","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Sheng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Ni","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4967-0844","authenticated-orcid":false,"given":"Xian\u2010Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Hainan Academy of Medical Sciences Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659\u2010015\u20100081\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md16110408"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.984801"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202000229"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/md16010012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13071021"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5c00679"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c05307"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2026.135309"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/md14020037"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2025.2464690"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.109723"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107919"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2026.109574"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202400752"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c01065"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.106709"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41429\u2010019\u20100250\u20104"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/np040063l"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100788h"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15063993"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600\u2010024\u201004458\u20105"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200917627"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol100298h"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2015.36"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14030159"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107417"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00742"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.2036"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b06812"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2016.01.015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600\u2010009\u20109360\u20108"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/md15030071"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2022.105252"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00255a022"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2025.105174"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2011.559947"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010014\u20100478\u20102"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000001507"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u201000324\u20108"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.774957"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b02396"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202403319"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.ra118.005103"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71678","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71678","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:54:33Z","timestamp":1790542473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cbdv.71678"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71678","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71678"}}