{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:03Z","timestamp":1790542683575,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Five\n                    <jats:italic>Strobilanthes<\/jats:italic>\n                    species indigenous to the Kumaun Himalayan region of Uttarakhand, India, have been historically employed in traditional medicine to treat bacterial infections, inflammatory conditions, and respiratory ailments, but remain largely unexplored for aquaculture disease management applications. Dichloromethane extracts of\n                    <jats:italic>S. glutinosa<\/jats:italic>\n                    (SGDE),\n                    <jats:italic>S. pentastemonoides<\/jats:italic>\n                    (SPDE),\n                    <jats:italic>S. angustifrons<\/jats:italic>\n                    (SADE),\n                    <jats:italic>S. attenuata<\/jats:italic>\n                    (SATDE) and\n                    <jats:italic>S. tomentosa<\/jats:italic>\n                    (STDE) were comprehensively analysed by GC\u2010MS for phytochemical profiling, with antioxidant activity quantified using DPPH radical scavenging and ferrozine\u2010based metal chelating assays, and antibacterial efficacy evaluated against\n                    <jats:italic>Aeromonas salmonicida<\/jats:italic>\n                    and\n                    <jats:italic>Edwardsiella tarda<\/jats:italic>\n                    using disc diffusion methodology. Pearson correlation analysis, molecular docking, and ADMET computational modelling were performed to elucidate structure\u2010activity relationships and pharmacokinetic properties. GC\u2010MS analysis identified 42\u201059 phytochemical constituents per species, with sterols and triterpenes constituting the predominant class. STDE demonstrated superior DPPH radical scavenging activity, while SATDE exhibited optimal metal chelating potential. SGDE and STDE displayed the good antibacterial activities against both pathogens. Pearson correlation analysis identified n\u2010tritriacontane and sclareol associated with antimicrobial activity, while molecular docking revealed superior binding affinities for \u03b2\u2010amirone to DNA topoisomerase I and \u03b2\u2010amyrin. ADMET assessment identified sclareol, stigmasterol, and 24\u2010epicampesterol as optimal candidates with favorable.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71680","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:09:36Z","timestamp":1788523776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GC\u2013MS\u2010Based Phytochemical Profiling and Integrated Evaluation of Antioxidant, Antibacterial, and\n                    <i>In Silico<\/i>\n                    Studies of Kumaun Himalayan\n                    <i>Strobilanthes<\/i>\n                    Species"],"prefix":"10.1002","volume":"23","author":[{"given":"Sakshi","family":"Negi","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Basic Sciences and Humanities G.B. Pant University of Agriculture and Technology  U.S. Nagar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0296-5231","authenticated-orcid":false,"given":"Ravendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Basic Sciences and Humanities G.B. Pant University of Agriculture and Technology  U.S. Nagar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9205-754X","authenticated-orcid":false,"given":"Vaishnavi","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Basic Sciences and Humanities G.B. Pant University of Agriculture and Technology  U.S. Nagar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3419-5119","authenticated-orcid":false,"given":"Pooja","family":"Bargali","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Basic Sciences and Humanities G.B. Pant University of Agriculture and Technology  U.S. Nagar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0328-4434","authenticated-orcid":false,"given":"Aashish","family":"Kumar Sagar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Basic Sciences and Humanities G.B. Pant University of Agriculture and Technology  U.S. Nagar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riddhiman","family":"Lahiri","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Basic Sciences and Humanities G.B. Pant University of Agriculture and Technology  U.S. Nagar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-0885","authenticated-orcid":false,"given":"Shilpi","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology, College of Agriculture G.B. Pant University of Agriculture and Technology  U.S. Nagar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0216-3439","authenticated-orcid":false,"given":"Avdhesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Aquaculture, College of Fisheries G.B. Pant University of Agriculture and Technology  U.S. Nagar Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmohan","family":"Singh Rawat","sequence":"additional","affiliation":[{"name":"Uttarakhand State Council For Science &amp; Technology (UCOST)  Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2552-3632","authenticated-orcid":false,"given":"Jolanta","family":"Maslowiecka","sequence":"additional","affiliation":[{"name":"Institute of Forest Sciences, Bialystok Technology University  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery A.","family":"Isidorov","sequence":"additional","affiliation":[{"name":"Institute of Forest Sciences, Bialystok Technology University  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-2709","authenticated-orcid":false,"given":"Dharmendra S.","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, College of Basic Sciences and Humanities G.B. 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