{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:03Z","timestamp":1790542683612,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Novel pyridine derivative platinium complexes, \u2010bis(2,4\u2010dimethylpyridine)dichloroplatinum(II), [PtCl\n                    <jats:sub>2<\/jats:sub>\n                    L\n                    <jats:sup>1<\/jats:sup>\n                    <jats:sub>2<\/jats:sub>\n                    ], bis(2\u2010amino\u20105\u2010 chloropyridine)dichloroplatinum(II), [PtCl\n                    <jats:sub>2<\/jats:sub>\n                    L\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sub>2<\/jats:sub>\n                    ] and bis(3\u2010amino\u20102\u2010chloropyridine)dichloroplatinum(II), [PtCl\n                    <jats:sub>2<\/jats:sub>\n                    L\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sub>2<\/jats:sub>\n                    ]\u2010 were synthesized and characterized via FT\u2010IR, UV\u2010Vis,\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR techniques and elemental analysis. The spectral assignment to structural data were corroborated via DFT\/ MPW1PW91\/LanL2DZ basic set. Vibrational transitions were conferred to the complexes by potential energy distribution analysis. Molecular electrostatic potential maps, frontier molecular orbitals and Mulliken charge distribution were calculated and the active regions of the molecules were determined. The interaction between 2ITO \u2013a lung cancer protein\u2010 and the complexes was investigated by molecular docking. Protein\u2010ligand interactions established that the lung cancer cell interact more strongly with the [PtCl\n                    <jats:sub>2<\/jats:sub>\n                    L\n                    <jats:sup>1<\/jats:sup>\n                    <jats:sub>2<\/jats:sub>\n                    ] and the [PtCl\n                    <jats:sub>2<\/jats:sub>\n                    L\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sub>2<\/jats:sub>\n                    ] complexes than the [PtCl\n                    <jats:sub>2<\/jats:sub>\n                    L\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sub>2<\/jats:sub>\n                    ] complex. Cytotoxicity of the complexes against A549 and Beas\u20102B normal lung cells via MTT colorimetric assay revealed that [PtCl\n                    <jats:sub>2<\/jats:sub>\n                    L\n                    <jats:sup>1<\/jats:sup>\n                    <jats:sub>2<\/jats:sub>\n                    ], [PtCl\n                    <jats:sub>2<\/jats:sub>\n                    L\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sub>2<\/jats:sub>\n                    ] complexes most effective against lung cancer cell linesA549 and Beas\u20102B over the incubation period of 24 h. These results suggest promising in\u2010vitro toxicity against the A549 and Beas\u20102B that warrants furthest test in an animal model.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71682","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:34:31Z","timestamp":1789468471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, In Vitro Cytotoxic Evaluation, DFT Calculation and Molecular Docking for Novel Pyridine Derivative Platinum Complexes"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0211-1006","authenticated-orcid":false,"given":"Emine","family":"Kutlu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-2940","authenticated-orcid":false,"given":"Fatih Mehmet","family":"Emen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3792-5993","authenticated-orcid":false,"given":"Canan Vejselova","family":"Sezer","sequence":"additional","affiliation":[{"name":"Faculty of Arts and Sciences, Department of Biology Kutahya Dumlup\u0131nar University  K\u00fctahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan Kaya","family":"K\u0131nayt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Nanoscience and Nanotechnology, Faculty of Arts and Sciences Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Mehtap","family":"Kutlu","sequence":"additional","affiliation":[{"name":"Department of Advanced Technologies Eskisehir Technical University  Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","first-page":"759","article-title":"'Polyamine Metabolism and Its Importance in Neoplastic Growth and as a Target for Chemotherapy","volume":"48","author":"Pegg A. E.","year":"1988","journal-title":"Cancer Research"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.725"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/205698a0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/222385a0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867054637626"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200600151"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959\u20108049(98)00224\u2010X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162\u20100134(99)00141\u20105"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040\u20108428(01)00219\u20100"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867023369376"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00016a004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2003.08.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic981181x"},{"key":"e_1_2_9_16_1","first-page":"389","article-title":"'New Software for Searching the Cambridge Structural Database and Visualizing Crystal Structures","volume":"58","author":"Bruno I. J.","year":"2002","journal-title":"Structural Science"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.76986"},{"key":"e_1_2_9_18_1","volume-title":"Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part B: Applications in Coordination, Organometallic, and Bioinorganic Chemistry","author":"Nakamoto K.","year":"2009"},{"key":"e_1_2_9_19_1","volume-title":"Low\u2010Frequency Vibrations of Inorganic and Coordination Compounds","author":"Ferraro J. R.","year":"1995"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic50023a008"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020\u20101693(00)81954\u20104"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169\u2010409X(00)00129\u20100"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130191"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973\u2010019\u201008242\u20104"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2021.115492"},{"key":"e_1_2_9_27_1","unstructured":"M. J.Frisch G. W.Trucks H. B.Schlegel et al. \u201cGaussian 09 Gaussian Inc \u201d Wallingford (2009)."},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2014.10.069"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00257"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2009.09.006"},{"key":"e_1_2_9_31_1","unstructured":"R.Dennington T.Keith andJ.Millam \u201cSemichem inc \u201d Shawnee Mission KS GaussView Version 5.8(2009)."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2013.05.096"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10379"},{"key":"e_1_2_9_34_1","unstructured":"W. L.DeLano \u201cPymol: An Open\u2010Source Molecular Graphics Tool \u201dCCP4 Newsl. protein crystallogr40(2002):82\u201392."},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010\u20108545(90)80044\u2010T"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma16030897"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20102860(78)85003\u20100"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14050395"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2007.07.027"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2010.01.001"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.2445"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1DT11412C"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138261"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2009.07.004"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2017.09.104"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2022.116064"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2014.04.036"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202201177"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2023.2219820"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201500754"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2022.120891"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.08.050"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3mt00128h"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA00647C"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.4314\/bcse.v35i3.11"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2021.1890222"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.04.007"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00964"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.7897\/2277-4343.06254"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/cmi\/5585552"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.2147\/AABC.S392068"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895\u2010025\u201004363\u20102"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065\u2010022\u201000879\u2010x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.124422"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71682","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:55:22Z","timestamp":1790542522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":63,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cbdv.71682"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71682","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71682"}}