{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:43Z","timestamp":1790542723756,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22494691"],"award-info":[{"award-number":["22494691"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322064"],"award-info":[{"award-number":["82322064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Traditionally used in Kazakh folk medicine, the Asteraceae species\n                    <jats:italic>Taraxacum tianschanicum<\/jats:italic>\n                    and\n                    <jats:italic>Artemisia gracilescens<\/jats:italic>\n                    were investigated for their sesquiterpenoid profiles despite being rich in flavonoids and fatty acids, leading to the isolation of 10 sesquiterpenoids of three structural types. These include one previously undescribed germacrane (\n                    <jats:bold>1<\/jats:bold>\n                    ) and two known germacranes (\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>3<\/jats:bold>\n                    ) from\n                    <jats:italic>T. tianschanicum<\/jats:italic>\n                    , as well as two germacranes (\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    ), one guaiane (\n                    <jats:bold>6<\/jats:bold>\n                    ), and four eudesmanes (\n                    <jats:bold>7\u201310<\/jats:bold>\n                    ) from\n                    <jats:italic>A. gracilescens<\/jats:italic>\n                    . The structures of these compounds were established through comprehensive analysis of the spectroscopic data and electronic circular dichroism (ECD) calculations. Several compounds exhibited significant anti\u2010inflammatory effects (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.15\u20138.37 \u00b5M) with low cytotoxicity, and mechanistic studies on structurally distinct sesquiterpenoids\n                    <jats:bold>4<\/jats:bold>\n                    (germacrane\u2010type) and\n                    <jats:bold>8<\/jats:bold>\n                    (eudesmane\u2010type) revealed that both suppress IL\u20106, IL\u20101\u03b2, iNOS, and COX\u20102. Notably, unlike compound\n                    <jats:bold>4<\/jats:bold>\n                    , the activity of\n                    <jats:bold>8<\/jats:bold>\n                    involved suppression of the MAPK pathway, indicating a clear mechanistic divergence.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71683","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:54:22Z","timestamp":1789930462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2011Inflammatory Sesquiterpenoids From Two Asteraceae Plants Native to Kazakhstan: Isolation, Structural Elucidation, and Mechanistic Insights"],"prefix":"10.1002","volume":"23","author":[{"given":"Arailym","family":"Zhomartova","sequence":"first","affiliation":[{"name":"Ethnomedicine and Biofunctional Molecule Research Center State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"The Research Center for Medicinal Plants Al\u2010Farabi Kazakh National University  Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janar","family":"Jenis","sequence":"additional","affiliation":[{"name":"The Research Center for Medicinal Plants Al\u2010Farabi Kazakh National University  Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu\u2010Hong","family":"Fang","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Qian","family":"Wu","sequence":"additional","affiliation":[{"name":"Ethnomedicine and Biofunctional Molecule Research Center State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4053-4870","authenticated-orcid":false,"given":"Jian\u2010Min","family":"Yue","sequence":"additional","affiliation":[{"name":"Ethnomedicine and Biofunctional Molecule Research Center State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai Shandong Republic of 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