{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:43Z","timestamp":1790542723902,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Five dammarane\u2010type saponins (\n                    <jats:bold>1<\/jats:bold>\n                    \u2010\n                    <jats:bold>5<\/jats:bold>\n                    ) were isolated from the aerial parts of\n                    <jats:italic>Gynostemma pentaphyllum<\/jats:italic>\n                    , including two new compounds, 2\u03b1,3\u03b2,12\u03b2,19,20(\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010pentahydroxydammar\u201024\u2010ene 3\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010[\u03b2\u2010D\u2010glucopyranosyl\u2010(1\u21922)\u2010\u03b2\u2010D\u2010glucopyranoside]\u201020\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010[\u03b2\u2010D\u2010xylopyranosyl\u2010(1\u21926)\u2010\u03b2\u2010D\u2010glucopyranoside] (\n                    <jats:bold>1<\/jats:bold>\n                    ) and 12\u2010oxo\u20102\u03b1,3\u03b2,20(\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010trihydroxydammar\u201024\u2010ene 3\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010(\u03b2\u2010D\u2010glucopyranoside)\u201020\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010[\u03b2\u2010D\u2010xylopyranosyl\u2010(1\u21926)\u2010\u03b2\u2010D\u2010glucopyranoside] (\n                    <jats:bold>2<\/jats:bold>\n                    ). The structures were elucidated through various spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR). Compounds\n                    <jats:bold>1\u20133<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    exhibited osteogenic activity by stimulating alkaline phosphatase (ALP) activity, collagen synthesis, and calcium mineralization in mouse osteoblastic MC3T3\u2010E1 cells. Among these, compound\n                    <jats:bold>2<\/jats:bold>\n                    increased ALP activity by 1.30 \u00b1 0.07\u2010 and 1.59 \u00b1 0.16\u2010fold at 2 and 1\u00a0\u00b5g\/mL, respectively, whereas compound\n                    <jats:bold>1<\/jats:bold>\n                    increased collagen synthesis and calcium mineralization by 1.14 \u00b1 0.05\u2010 and 1.24 \u00b1 0.06\u2010fold at 1\u00a0\u00b5g\/mL, and compound\n                    <jats:bold>3<\/jats:bold>\n                    increased these parameters by 1.25 \u00b1 0.07\u2010 and 1.14 \u00b1 0.03\u2010fold at 2\u00a0\u00b5g\/mL, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71687","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:39:51Z","timestamp":1789036791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Osteogenic Activity of New Dammarane\u2010Type Saponins From\n                    <i>Gynostemma pentaphyllum<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7164-1421","authenticated-orcid":false,"given":"Nguyen Tuan","family":"Duong","sequence":"first","affiliation":[{"name":"Bac Giang Agriculture and Forestry University, Viet Yen  Bac Giang Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Thi Thu","family":"Ha","sequence":"additional","affiliation":[{"name":"Institute of Forestry and Sustainable Development University of Agriculture and Forestry Thai Nguyen University  Thai Nguyen Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong Thi Hai","family":"Yen","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8760-264X","authenticated-orcid":false,"given":"Do Thi","family":"Thao","sequence":"additional","affiliation":[{"name":"Institute of Biology VAST  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-3786","authenticated-orcid":false,"given":"Bui Huu","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-6990","authenticated-orcid":false,"given":"Phan","family":"Van Kiem","sequence":"additional","affiliation":[{"name":"Institute of Chemistry VAST  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2024.08.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2014.12.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105357"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2023.113744"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144964"},{"key":"e_1_2_9_7_1","first-page":"609","article-title":"Dictionary of Vietnamese Medicinal Plants","volume":"1","author":"Chi V. 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