{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:18Z","timestamp":1790546178397,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004063"],"award-info":[{"award-number":["82004063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803847"],"award-info":[{"award-number":["81803847"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ8173"],"award-info":[{"award-number":["2024JJ8173"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Five undescribed phenolic glycosides, ficuserectosides A\u2010E (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    ), and three previously reported congeners (\n                    <jats:bold>6<\/jats:bold>\n                    \u2013\n                    <jats:bold>8<\/jats:bold>\n                    ) were obtained from the whole plants of\n                    <jats:italic>Ficus erecta<\/jats:italic>\n                    . Their structures were determined by comprehensive analysis of 1D and 2D NMR and HRESIMS data. The identities and configurations of the monosaccharide units were established after hydrolysis and subsequent chiral derivatization followed by HPLC analysis. Notably, ficuserectoside E (\n                    <jats:bold>5<\/jats:bold>\n                    ) was established as a\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010configured prenylated coumarin glucoside, enabling revision of a previously misassigned related structure. All of the isolates were evaluated in lipopolysaccharide (LPS)\u2010stimulated RAW264.7 macrophages and in a 6\u2010hydroxydopamine (6\u2010OHDA)\u2010induced PC12 cell injury model. None of the compounds significantly inhibited nitric oxide (NO)\u00a0production at 25 or 50\u00a0\u00b5M. However, compounds\n                    <jats:bold>5<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    dose\u2010dependently (12.5\u201350\u00a0\u00b5M) improved PC12 cells survival, as evidenced by reduced intracellular reactive oxygen species (ROS)\u00a0accumulation and increased cellular glutathione (GSH) levels. The present findings not only broaden the structural spectrum of\n                    <jats:italic>Ficus erecta<\/jats:italic>\n                    phenolic glycosides but also highlight selected glycosylated phenolics as promising leads for antioxidant\u2010based neuroprotective candidates.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71692","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:18:16Z","timestamp":1789035496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenolic Glycosides From\n                    <i>Ficus erecta<\/i>\n                    and Their Anti\u2010Inflammatory and Neuroprotective Activities"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8770-6861","authenticated-orcid":false,"given":"Wenming","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyue","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7313-9907","authenticated-orcid":false,"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Hunan University of Medicine  Huaihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxue","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Hunan University of Medicine  Huaihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5242-0180","authenticated-orcid":false,"given":"An","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Hunan University of Medicine  Huaihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7042"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.12677\/acm.2025.152439"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1917569"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2023.105740"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2024.2379011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301037"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200182"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1994966"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2023.113886"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.4c01040"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400236"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28176426"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2023.104976"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977777"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118472"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.109120"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120592"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.607403"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2026.107256"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.05.015"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b01020"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(00)98072\u20105"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.38.1857"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744\u20107909.2007.00340.x"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71692","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71692","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:56:13Z","timestamp":1790542573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cbdv.71692"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71692","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71692"}}