{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:26Z","timestamp":1790542706188,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of substituted indolo[2,1\u2010b]quinazoline\u20106,12\u2010diones (SJ1\u2010SJ8), which consist of already published derivatives (SJ1\u2010SJ5) and newly synthesized derivatives (SJ6\u2010SJ8), has been studied for their possible \u03b1\u2010amylase inhibition property as an antidiabetic lead compound. The synthesized derivatives have been identified by spectroscopy and analysis methods and tested for their in vitro \u03b1\u2010amylase inhibitory activity. The most potent inhibitory activity among the tested derivatives was showed by SJ2 (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 18.49 \u00b1 0.06 \u00b5M), similar to the reference drug acarbose (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 16.26 \u00b1 0.02 \u00b5M). The second\u2010best activity was observed for the newly identified derivative SJ8 (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 19.67 \u00b1 0.19 \u00b5M). Molecular docking and 100\u00a0ns molecular dynamics simulations supported favorable and stable interactions of SJ2 in the \u03b1\u2010amylase active site, while MM\u2010PBSA analysis showed favorable binding energetics. The electronic properties of SJ2 were also clarified by DFT and molecular electrostatic potential analyzes, and in silico ADMET profiling indicated promising predicted drug\u2010like and pharmacokinetic properties. To summarize, SJ2 is a promising lead for \u03b1\u2010amylase inhibition, which needs further optimization and biological validation. Future evaluation against \u03b1\u2010glucosidase and relevant in vivo models will be essential to determine the more general antidiabetic potential of this scaffold.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71694","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:16:17Z","timestamp":1789035377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, Molecular Dynamics, and In Vitro Evaluation of Isatin\u2010Based Quinazoline Derivatives as Potential Antidiabetic Agents"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5560-3802","authenticated-orcid":false,"given":"Sahil","family":"Jaidka","sequence":"first","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University  Rajpura Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-9457","authenticated-orcid":false,"given":"Ankush","family":"Kumar","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University  Rajpura Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9058-6538","authenticated-orcid":false,"given":"Christopher","family":"Basumatary","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Technology IIT BHU  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1590","authenticated-orcid":false,"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University  Rajpura Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-8749","authenticated-orcid":false,"given":"Rohit","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy Chitkara University  Rajpura Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnac003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf177"},{"key":"e_1_2_10_4_1","first-page":"698","article-title":"Epidemiology of Diabetes","volume":"42","author":"Forouhi N. 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