{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:09Z","timestamp":1790546169450,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Water extract of\n                    <jats:italic>Semiliquidambar cathayensis<\/jats:italic>\n                    (WESC) exhibits favorable therapeutic effects against depression, yet its pharmacodynamic material basis and mechanism of action remain unclear. In this study, ultra\u2010high\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight mass spectrometry (UPLC\u2010Q\u2010TOF\u2010MS) was employed to analyze the chemical constituents of WESC. Network pharmacology and molecular docking were further applied to screen the antidepressant mechanism basis and potential targets of WESC. Lipopolysaccharide (LPS)\u2010induced mouse and PC12 cell models were established as in vivo depressive animal model and in vitro cellular injury model, respectively. Combined with pathological examination and molecular biological techniques, the antidepressant mechanism of WESC was systematically investigated. Results showed that a total of 14 chemical components were identified from WESC. Network pharmacology and molecular docking analyses indicated that GSK3\u03b2 was one of the key targets, and the active components in WESC possessed strong binding affinities with GSK3\u03b2, Axin1, and NF\u2010\u03baB. Pathological studies demonstrated that WESC significantly alleviated inflammatory infiltration in the mouse prefrontal cortex and hippocampal neuronal damage. Molecular biological analyses revealed that WESC markedly downregulated the expression of proteins related to the GSK3\u03b2\/NF\u2010\u03baB signaling pathway in LPS\u2010stimulated mice and PC12 cells, thereby attenuating neuroinflammation, promoting neural plasticity, and exerting antidepressant effects.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71695","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:52:06Z","timestamp":1789469526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Antidepressant Effect and Mechanism of Water Extract of\n                    <i>Semiliquidambar cathayensis<\/i>\n                    (WESC) Based on the GSK3\u03b2\/NF\u2010\u03baB Signaling Pathway"],"prefix":"10.1002","volume":"23","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"He","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Chinese Medicine and Pharmaceutical Science  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-5716","authenticated-orcid":false,"given":"Dongmei","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Chinese Medicine and Pharmaceutical Science  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Chinese Medicine and Pharmaceutical Science  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibiao","family":"Su","sequence":"additional","affiliation":[{"name":"College of Health Science Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongning","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Chinese Medicine and Pharmaceutical Science  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Chinese Medicine and Pharmaceutical Science  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedao","family":"lai","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Chinese Medicine and Pharmaceutical Science  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-8798","authenticated-orcid":false,"given":"Guining","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Guangxi Medical University  Nanning Guangxi China"},{"name":"Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards Guangxi Institute of Chinese Medicine and Pharmaceutical Science  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31948\u20102"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2025.174071"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2026.117120"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.120"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2203065"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6871089"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.04.002"},{"issue":"12","key":"e_1_2_11_10_1","first-page":"2113","article-title":"Metabolomics Study on the Intervention of Shugan Jieyu Anshen Formula for Coronary Heart Disease Complicated With Depression","volume":"22","author":"Ruihua C. 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