{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:10Z","timestamp":1790546170352,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tripterygium Glycoside Tablets (TGTs) are primary drugs for rheumatoid arthritis (RA) but pose a risk of nephrotoxicity.\n                    <jats:italic>Rubus chingii<\/jats:italic>\n                    Hu (RCH) may enhance kidney function. This study explores a combined RA treatment by examining RCH's chemical components and using a collagen\u2010induced arthritis (CIA) rat model to test TGTs with or without RCH. RCH boosted the therapeutic impact of TGTs in CIA rats, shown by decreased paw swelling, improved joint condition, and reduced serum TNF\u2010\u03b1, IL\u20106, and IL\u20101\u03b2 levels. The normalization of renal markers (BUN and Scr) and oxidative stress indicators (ROS, T\u2010NOS, and T\u2010SOD) may be associated with the Nrf2\/NF\u2010\u03baB pathway. Metabolomics indicated that RCH may counteract nephrotoxicity by influencing the metabolism of glycine, serine, threonine, tryptophan, histidine, taurine, and sulfaurine. In summary, RCH synergizes with TGTs to treat RA by inhibiting inflammation, affecting metabolic pathways, reducing oxidative stress, and minimizing kidney toxicity, offering a new treatment strategy for RA.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71696","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:15:21Z","timestamp":1789467321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolomics and Mechanistic Approaches Reveal the Synergistic and Attenuating of\n                    <i>Rubus chingii<\/i>\n                    Hu on Tripterygium Glycoside Tablets in the Treatment of Rheumatoid Arthritis"],"prefix":"10.1002","volume":"23","author":[{"given":"Cong","family":"Zhang","sequence":"first","affiliation":[{"name":"Kunshan Rehabilitation Hospital  Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zepeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Hospital of Kunshan  Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yan","sequence":"additional","affiliation":[{"name":"Kunshan Rehabilitation Hospital  Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-1799","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Hospital of Kunshan  Kunshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.753400"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2024.116522"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.812631"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114368"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1282610"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.747922"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010022\u201004011\u20106"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1052504"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061192"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875\u20105364(20)30048\u20100"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4268\/cjcmm20161129"},{"issue":"12","key":"e_1_2_10_13_1","first-page":"1636","article-title":"Treatment of Chronic Primary Glomerulopathy Patients of Shen Deficiency and dampness heat Syndrome by yishen qingli Granule Combined Low\u2010dose Tripterygium wilfordii Multiglycoside Tablet: A Clinical Efficacy Observation","volume":"33","author":"Sheng M.\u2010X.","year":"2013","journal-title":"Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi Jiehe Zazhi= Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29102198"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116782"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010016\u20101526\u2010x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c03948"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.13702\/j.1000\u20100607.20220952"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255\u2010021\u201003015\u20101"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120734"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b03912"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2022.06.011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5654"},{"issue":"8","key":"e_1_2_10_24_1","first-page":"5420","article-title":"Candidate Metabolite Markers of Peripheral Neuropathy in Chinese Patients With Type 2 Diabetes","volume":"14","author":"Shao M.\u2010M.","year":"2022","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14121431"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001\u20101528.2025.04.002"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001\u20101528.2025.04.002"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001\u20101528.2025.04.002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001\u20101528.2025.04.002"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1001\u20101528.2025.04.002"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11050746"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.608703"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117100"},{"issue":"1","key":"e_1_2_10_34_1","first-page":"36","article-title":"Reproductive Systemic Toxicity and Mechanism of Glucosides of Tripterygium wilfordii Hook. F. (GTW)","volume":"49","author":"Guo J.","year":"2019","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111128"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2015.8"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods13233791"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.07.157"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787\u2010022\u201000930\u20102"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.03.027"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24081589"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.08.260"},{"issue":"1","key":"e_1_2_10_43_1","first-page":"1","article-title":"Psychiatric Morbidity Associated With Some Cytokines (IL\u20101beta, IL\u201012, IL\u201018 and TNF\u2010alpha) Among Rheumatoid Arthritis Patients","volume":"15","author":"El\u2010Tantawy A. M.","year":"2008","journal-title":"Egyptian journal of Immunology"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.10.021"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnma.2017.02.007"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.12.012"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen\u20102017\u2010000438"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2018.0270"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01250"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.13422\/j.cnki.syfjx.20200107"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156589"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00394"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117029"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.4103\/wjtcm.wjtcm_27_19"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110047"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101266"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101186"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106126"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.01.001"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.10.026"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14096"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.03.025"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.1c00110"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104838"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.60.261"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70630"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00236.2012"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203720666190305163135"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010024\u201000872\u20108"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.03.026"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2025.101092"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423\u20100127\u201017\u2010S1\u2010S4"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.06.011"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010018\u20100218\u20105"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:56:10Z","timestamp":1790542570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":73,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cbdv.71696"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71696","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71696"}}