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This systematic review aimed to evaluate the potential of\n                    <jats:italic>P. edulis<\/jats:italic>\n                    on DM based on preclinical evidence from in vivo studies. This review was performed according to the PRISMA guide, using a structured search on the Embase, PubMed\u2010Medline, Web of Science, Cochrane and Scopus platforms. Twenty\u2010two studies met the inclusion criteria, and 18 reported antihyperglycemic effects of the plant, either alone or as an adjunct to insulin. Additional benefits included improvements in lipid and antioxidant profiles. The fruit was used in 16 studies, with the peel being the most frequent and effective part (11 studies), likely related to its high content of pectin, phenolics, and flavonoids. Proposed mechanisms include delayed intestinal glucose absorption, stimulation of insulin secretion, partial regeneration of pancreatic \u03b2\u2010cells, activation of the PI3K\/AKT and AMPK pathways, and antioxidant and hypolipidemic actions. Despite these promising findings, significant methodological limitations, such as lack of dose and extraction process standardization and insufficient phytochemical characterization, affect reproducibility. Nevertheless, the data suggest that passion fruit peel, an often\u2010discarded agro\u2010industrial by\u2010product, may represent a promising source of bioactive compounds for diabetes research.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71700","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:27:19Z","timestamp":1792520839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Review of Antidiabetic Mechanisms of\n                    <i>Passiflora edulis<\/i>\n                    : Beyond Glycemic Control"],"prefix":"10.1002","volume":"23","author":[{"given":"Luiz Ricardo Teixeira","family":"de Farias","sequence":"first","affiliation":[{"name":"Department of Pharmacy Federal University of Rio Grande do Norte  Natal Rio Grande do Norte 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