{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:40Z","timestamp":1790542720249,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer remains a major global health challenge, particularly as several tumors develop resistance to current therapies. Although doxorubicin is widely used to treat various cancers, its effectiveness is often limited by adverse effects, including cardiotoxicity and nephrotoxicity, which restrict its dosing. In search of safer and more effective options, a series of novel piperidine\u2013embedded isoxazol\u2013triazole conjugates (\n                    <jats:bold>6a\u20106o<\/jats:bold>\n                    ) were designed, synthesized, and biologically evaluated against the MCF\u20107 cell line in this study. The synthesized compounds\n                    <jats:bold>6a\u20106o<\/jats:bold>\n                    were characterized using FTIR, HRMS, and\n                    <jats:sup>1<\/jats:sup>\n                    H and\n                    <jats:sup>13<\/jats:sup>\n                    C NMR spectroscopy analysis to confirm their structure and verify successful synthesis. The GI\n                    <jats:sub>50<\/jats:sub>\n                    (Growth Inhibition 50%) values of synthesized compounds\n                    <jats:bold>6a\u20106o<\/jats:bold>\n                    were determined using the SRB assay. Among all synthesized compounds,\n                    <jats:bold>6m<\/jats:bold>\n                    exhibited the most potent antiproliferative activity against MCF\u20107 cells, having GI50 &lt;10 \u00b5g\/mL (SI &gt;5), comparable to adriamycin (doxorubicin, GI\n                    <jats:sub>50<\/jats:sub>\n                    &lt;10 \u00b5g\/mL). Overall,\n                    <jats:bold>6m<\/jats:bold>\n                    is a novel anticancer agent with promising abilities against MCF\u20107 human breast cancer. The results support the compounds relevance as a biologically active agent with effective proliferation\u2010suppressive properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71702","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:10:31Z","timestamp":1789931431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Anticancer Potential of Novel Piperidine\u2010Embedded Isoxazol\u2013Triazole Conjugates Against MCF\u20107 Human Breast Adenocarcinoma Cell Line: Design, Synthesis, In Silico, and In Vitro Investigations"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9950-6873","authenticated-orcid":false,"given":"Jay R.","family":"Ghonia","sequence":"first","affiliation":[{"name":"Department of Chemistry Sardar Vallabhbhai National Institute of Technology  Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigisha","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Sardar Vallabhbhai National Institute of Technology  Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-9558","authenticated-orcid":false,"given":"Bharatkumar Z.","family":"Dholakiya","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sardar Vallabhbhai National Institute of Technology  Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"#cr-split#-e_1_2_9_2_1.1","doi-asserted-by":"crossref","unstructured":"M.Aljurf N. 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