{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:43Z","timestamp":1790542723837,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005273","name":"Natural Science Foundation of Yunnan Province","doi-asserted-by":"publisher","award":["202601AT070228"],"award-info":[{"award-number":["202601AT070228"]}],"id":[{"id":"10.13039\/501100005273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Eleven characteristic monoterpenoid indole alkaloids from\n                    <jats:italic>Uncaria rhynchophylla<\/jats:italic>\n                    were isolated, structurally assigned, and evaluated in parallel for inhibitory effects on human Na\n                    <jats:sub>v<\/jats:sub>\n                    1.7, Na\n                    <jats:sub>v<\/jats:sub>\n                    1.5, Ca\n                    <jats:sub>v<\/jats:sub>\n                    3.1, and K\n                    <jats:sub>v<\/jats:sub>\n                    1.5 channels using whole\u2010cell patch\u2010clamp recordings. Na\n                    <jats:sub>v<\/jats:sub>\n                    1.7 and Na\n                    <jats:sub>v<\/jats:sub>\n                    1.5 showed the broadest responses, with active inhibitors displaying micromolar IC\n                    <jats:sub>50<\/jats:sub>\n                    values against the two sodium channels. Corynanthe\u2010type alkaloids were the main contributors to Ca\n                    <jats:sub>v<\/jats:sub>\n                    3.1 inhibition, whereas K\n                    <jats:sub>v<\/jats:sub>\n                    1.5 was less sensitive and responded mainly to rhynchophylline and isorhynchophylline. The observed channel preferences were associated with alkaloid chemotype and structural features. This comparative analysis reveals differential activity across the four ion channels examined and provides a basis for further electrophysiological and mechanistic studies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71703","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:33:54Z","timestamp":1789036434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ion\u2010Channel Activity of Characteristic Alkaloids From\n                    <i>Uncaria rhynchophylla<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2268-1548","authenticated-orcid":false,"given":"Wen\u2010Yan","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Natural Medicines Chinese Academy of Sciences Kunming Institute of Botany  Kunming P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Natural Medicines Chinese Academy of Sciences Kunming Institute of Botany  Kunming P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Natural Medicines Chinese Academy of Sciences Kunming Institute of Botany  Kunming P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570161117666190704092841"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.02.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.06.011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2026.1723499"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2020.104772"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112960"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010025\u201001475\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1071068"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118869"},{"issue":"4","key":"e_1_2_10_11_1","first-page":"685","article-title":"Advances in Indole Alkaloids From Traditional Chinese Medicine of Uncariae Ramulus Cum Uncis Documented in Chinese Pharmacopoeia","volume":"44","author":"Zhang J. 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