{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:40Z","timestamp":1790542720219,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Uterine fibroids (leiomyomas) are hormone\u2010dependent benign tumors driven by progesterone and estradiol. This study investigated the multi\u2010mechanistic effects of\n                    <jats:italic>Xylopia aethiopica<\/jats:italic>\n                    on fibroid pathophysiology using in vivo and in silico approaches. Thirty Wistar rats were induced with fibroids via monosodium glutamate (MSG) and treated with varying doses (100, 200, 400\u00a0mg\/kg) of\n                    <jats:italic>X. aethiopica<\/jats:italic>\n                    extract. Serum progesterone and estradiol were measured, and molecular docking and protein\u2013protein interaction analyses assessed potential mechanisms. MSG significantly elevated progesterone (30.12\u00a0\u00b1\u00a02.43\u00a0ng\/mL) and estradiol (48.56\u00a0\u00b1\u00a03.24\u00a0pg\/mL), while\n                    <jats:italic>X. aethiopica<\/jats:italic>\n                    normalized these hormones in a dose\u2010dependent manner. Docking studies revealed strong interactions of bioactive compounds, including aporphine, xylopioxyde, and liriodenine with progesterone, estrogen, VEGFR2, and TGF\u2010\u03b2 receptors, suggesting hormonal, anti\u2010angiogenic, and anti\u2010fibrotic effects. These findings indicate that\n                    <jats:italic>X. aethiopica<\/jats:italic>\n                    exerts pleiotropic actions to restore endocrine balance and inhibit fibroid\u2010promoting pathways, supporting its potential as a natural, multi\u2010targeted therapeutic agent for uterine fibroids.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71704","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:48:44Z","timestamp":1789465724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Mechanistic Effects of\n                    <i>Xylopia aethiopica<\/i>\n                    Fruits on Uterine Fibroids: Insights From In Vivo and In Silico Evidence"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-3695","authenticated-orcid":false,"given":"Adedokun","family":"Oluwasegun","sequence":"first","affiliation":[{"name":"CBIOS \u2013 Research Center for Bioscience and Health Technologies Universidade Lusofona  Lisbon Portugal"},{"name":"Cancer and Reproductive Research Group College of Pharmacy Igbinedion University  Okada Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-9947","authenticated-orcid":false,"given":"Ume","family":"Ogochukwu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Igbinedion University  Okada Nigeria"},{"name":"Cancer and Reproductive Research Group College of Pharmacy Igbinedion University  Okada Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8948-9871","authenticated-orcid":false,"given":"Akinsola","family":"Olubiyi","sequence":"additional","affiliation":[{"name":"Department of Physiology (Pharmacology unit) Faculty of Medical Sciences Redeemer's University  Ede Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6653-8784","authenticated-orcid":false,"given":"Agada","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Igbinedion University  Okada Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5273-0079","authenticated-orcid":false,"given":"Adebiyi","family":"Omowumi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Igbinedion University  Okada Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idogho","family":"Eseoghena","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Igbinedion University  Okada Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adedokun","family":"Folake","sequence":"additional","affiliation":[{"name":"Cancer and Reproductive Research Group College of Pharmacy Igbinedion University  Okada Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6006-9889","authenticated-orcid":false,"given":"Adekunle","family":"Temilade","sequence":"additional","affiliation":[{"name":"CBIOS \u2013 Research Center for Bioscience and Health Technologies Universidade Lusofona  Lisbon Portugal"},{"name":"Cancer and Reproductive Research Group College of Pharmacy Igbinedion University  Okada Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1045783"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.09.037"},{"key":"e_1_2_10_4_1","first-page":"650","article-title":"Risk Factors for Adenomyosis in Patients With Symptomatic Uterine Leiomyomas","volume":"81","author":"Romanek K.","year":"2010","journal-title":"Ginekologia Polska"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12775\/JEHS.2024.59.009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.04.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000164"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201033607\u20102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13102"},{"key":"e_1_2_10_10_1","first-page":"803","article-title":"A Review of the Anti\u2010Fibroid Potential of Medicinal Plants: Mechanisms and Targeted Signaling Pathways","volume":"5","author":"Koyejo O. 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