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Understanding how such environmental pressures contribute to shaping its metabolic profiles is key to supporting conservation and sustainable valorization strategies based on the responsible use of renewable plant biomass, while reducing pressure on wild populations. This study compared the phytochemical composition and bioactivities of leaf extracts from two ecotypes collected in southern Portugal. Leaves were selected as a renewable and understudied organ with antioxidant and pharmacological potential. Both ecotypes were rich in (poly)phenols, mainly flavonoids, along with phenolic acids, triterpenoids, and representatives of coumarin and anthraquinone, and exhibited strong antioxidant capacity. The Vila Real de Santo Ant\u00f3nio ecotype (CL1), exposed to higher solar radiation and drought, accumulated more total (poly)phenolics, hydroxycinnamic acids, and flavonoids, displaying stronger copper\u2010chelating and cytotoxic activities. Conversely, the Aljezur ecotype (CL2), from a cooler and more humid habitat, was richer in flavonols, hydroxybenzoic acids, and organic acids, supporting efficient redox\u2010based antioxidant protection with lower cytotoxicity. These ecotypic differences reveal adaptive metabolic strategies that enhance stress resilience, highlighting\n                    <jats:italic>C. album<\/jats:italic>\n                    leaves as a promising renewable source of bioactive compounds for functional and sustainable health applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71705","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:05:43Z","timestamp":1789931143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contrasting Coastal Environments Are Associated With Ecotype\u2010Specific Leaf Polyphenolic Profiles and Bioactivity in\n                    <i>Corema album<\/i>\n                    subsp.\n                    <i>album<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-8353","authenticated-orcid":false,"given":"Eliana","family":"Fernandes","sequence":"first","affiliation":[{"name":"Centre of Marine Sciences (CCMAR\/CIMAR LA), Faculty of Sciences and Technology University of Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-3364","authenticated-orcid":false,"given":"Riccardo","family":"Trentin","sequence":"additional","affiliation":[{"name":"Department of Biology University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-710X","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR\/CIMAR LA), Faculty of Sciences and Technology University of Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4338-7703","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Cust\u00f3dio","sequence":"additional","affiliation":[{"name":"Centre of Marine Sciences (CCMAR\/CIMAR LA), Faculty of Sciences and Technology University of Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"C. 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