{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:57:53Z","timestamp":1790542673364,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFD0800401"],"award-info":[{"award-number":["2018YFD0800401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To discover novel green bio\u2010based insecticidal lead compounds, six polyketides, including two new compounds, strekingmycin I (\n                    <jats:bold>5<\/jats:bold>\n                    ) and strekingmycin J (\n                    <jats:bold>6<\/jats:bold>\n                    ), together with four known analogues, were isolated and identified from the fermentation products of earthworm gut\u2010derived\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    sp. SA61. Their structures were established by comprehensive spectroscopic analysis, including NMR, HR\u2010ESI\u2010MS, and single\u2010crystal x\u2010ray diffraction. Notably, the crystallographic data of strekingmycin G (\n                    <jats:bold>3<\/jats:bold>\n                    ) were obtained for the first time, which unambiguously confirmed its absolute configuration. In insecticidal activity assays against the third\u2010instar nymphs of\n                    <jats:italic>Bemisia tabaci<\/jats:italic>\n                    , all six compounds exhibited varying degrees of toxicity. Among them, strekingmycin A (\n                    <jats:bold>1<\/jats:bold>\n                    ) displayed the most potent activity, with an LC\n                    <jats:sub>50<\/jats:sub>\n                    value of 5.58 \u00b5g\/mL, which was within the same concentration range as that of the positive control spirotetramat, albeit less active than the commercial standard. This study enriches the structural diversity of\n                    <jats:italic>strekingmycin<\/jats:italic>\n                    \u2010type polyketides by reporting two new derivatives and providing the first crystallographic evidence for compound\n                    <jats:bold>3<\/jats:bold>\n                    . Furthermore, it demonstrates for the first time the insecticidal potential of the strekingmycin family against\n                    <jats:italic>B. tabaci<\/jats:italic>\n                    , offering a scientific basis for further research on the management of piercing\u2010sucking pests.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71706","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:00:53Z","timestamp":1789470053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two New Polyketides From\n                    <i>Streptomyces<\/i>\n                    sp. SA61: Isolation, Structure Elucidation, and Insecticidal Activity Against\n                    <i>Bemisia tabaci<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1600-5495","authenticated-orcid":false,"given":"Pengfei","family":"Cui","sequence":"first","affiliation":[{"name":"College of Plant Protection Shenyang Agricultural University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Plant Protection Shenyang Agricultural University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0909-6788","authenticated-orcid":false,"given":"Zhaoyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Plant Protection Shenyang Agricultural University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Plant Protection Shenyang Agricultural University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Plant Protection Shenyang Agricultural University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744\u20107917.13501"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20077"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14051104"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.07.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2023.01.012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2122099119"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.03571\u201012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010virology\u2010031413\u2010085410"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1011163"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/toad089"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2025.1704832"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1286"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266436607260106072004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02203"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2021.104877"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.01.009"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1705702"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b07141"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14122395"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2025.124390"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.2c00961"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12102031"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.45.892"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2007.11.004"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/aesa\/87.2.195"}],"container-title":["Chemistry &amp; 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