{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:43Z","timestamp":1790542723831,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Furanocoumarins are plant\u2010derived compounds with diverse biological activities and emerging therapeutic potential. This study evaluated the anticancer and anti\u2010angiogenic properties of bergaptol by using MDA\u2010MB\u2010231, HepG2, and HeLa cancer cell lines, as well as HUVEC endothelial cells, with HDFs serving as the healthy control group. Cell viability, apoptosis, cell\u2010cycle progression, and angiogenesis were evaluated using complementary two\u2010dimensional (2D) and three\u2010dimensional (3D) experimental models. Bergaptol exhibited selective cytotoxicity toward cancer and endothelial cells, with no apparent cytotoxicity toward HDFs. Treatment induced apoptosis, disrupted cell\u2010cycle progression, and suppressed angiogenic activity. In 3D models, bergaptol reduced spheroid viability, diminished spheroid size, and decreased endothelial cell content. An\n                    <jats:italic>ex vivo<\/jats:italic>\n                    assay, the chorioallantoic membrane (CAM) assay, corroborated these observations, demonstrated a substantial inhibition of neovascularization, and further supports its anti\u2010angiogenic potential. These findings demonstrate that bergaptol exhibits both anticancer and anti\u2010angiogenic activity in 2D and 3D experimental models supporting further evaluation of bergaptol as a potential anticancer agent.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71707","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:29:47Z","timestamp":1789972187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Anticancer and Anti\u2010Angiogenic Efficacy of Bergaptol in 2D and 3D Tumor Microtissue Models"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1308-4915","authenticated-orcid":false,"given":"Buse","family":"Bekar","sequence":"first","affiliation":[{"name":"Faculty of Science Department of Biology Hacettepe University  Beytepe Ankara 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