{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:57:53Z","timestamp":1790542673298,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Libidibia ferrea<\/jats:italic>\n                    is traditionally medicine used in northeastern Brazil; however, studies addressing chemically characterized extracts and pharmacological properties remain limited. This study investigated the chemical composition and anti\u2010neuroinflammatory activity of a dry extract of\n                    <jats:italic>L. ferrea<\/jats:italic>\n                    (DELF) in lipopolysaccharide (LPS)\u2010stimulated microglial cells, as well as its possible mechanisms of action. The extract was characterized using UPLC\u2010ESI\u2010QTOF\u2010MS, and methyl gallate, the major compound, was quantified (38.15\u00a0\u00b5g\/mg dry extract). Cytotoxicity in BV\u20102 cells was evaluated by the MTT assay. Antioxidant activity was assessed using free radical scavenging assays, while nitric oxide (NO) and IL\u20106 levels were determined using the Griess reaction and ELISA. iNOS expression was analyzed by western blotting. Eighteen compounds were identified, including phenolic acids, flavonoids, and hydroxy fatty acids. DELF also presented relevant mineral content. The extract (up to 100\u00a0\u00b5g\/mL) and methyl gallate (up to 1.9\u00a0\u00b5g\/mL) were non\u2010cytotoxic. DELF at 100\u00a0\u00b5g\/mL reduced nitrite release by 67% in LPS\u2010stimulated cells and significantly reduced IL\u20106 production by 55%. DELF decreased NO levels without altering iNOS expression and exhibited antioxidant activity (90.16% DPPH, 83.6% superoxide, and \u223c45% hydroxyl radical scavenging at 100\u00a0\u00b5g\/mL). These findings highlight DELF as a promising source of bioactive compounds with potential anti\u2010neuroinflammatory applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71708","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:19:16Z","timestamp":1790540356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Profile, Antioxidant Activity, and Anti\u2010Neuroinflammatory Effects of a Novel Dry Extract of\n                    <i>Libidibia ferrea<\/i>\n                    in Microglial Cells"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-0188","authenticated-orcid":false,"given":"Francisco Cirineu das","family":"Chagas Neto","sequence":"first","affiliation":[{"name":"Center for Pharmaceutical and Cosmetic Studies Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-6125","authenticated-orcid":false,"given":"Kirley Marques","family":"Canuto","sequence":"additional","affiliation":[{"name":"Embrapa Tropical Agroindustry Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arcelina Pacheco","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-5403","authenticated-orcid":false,"given":"N\u00e1gila Maria","family":"Pontes Silva Ricardo","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-6093","authenticated-orcid":false,"given":"Ana Bruna","family":"De Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical and Cosmetic Studies Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Vin\u00edcius Clemente","family":"Serra Azul","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical and Cosmetic Studies Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo R. V.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Embrapa Tropical Agroindustry Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Maria","family":"Pontes Th\u00e9","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical and Cosmetic Studies Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nia Torres \u00c1vila","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical and Cosmetic Studies Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3826-2677","authenticated-orcid":false,"given":"Luzia Kalyne Almeida Moreira","family":"Leal","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical and Cosmetic Studies Faculty of Pharmacy, Dentistry and Nursing Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"743","article-title":"Brazilian Tree Species","volume":"1","author":"Carvalho P. 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