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Over the past two decades, substantial advances have been made in the design of potent, selective, and pharmacokinetically optimized Akt inhibitors. This review analyzes recent Akt inhibitors, with particular focus on the structure\u2013activity relationship (SAR) of their heterocyclic core scaffolds and the resulting biological activity. Additional strategies identified in this review that have yielded promising preclinical and clinical candidates include scaffold optimization, conformational restriction, and hybrid design. Special emphasis is given to advanced inhibitors such as capivasertib, ipatasertib, and NTQ1062, which illustrate the influence of pharmacophoric refinement on therapeutic success. 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