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Phytochemical investigation of crude extracts allowed the isolation and spectroscopic identification of 15 secondary metabolites. \u03b1\u2010Amylase inhibitory and anti\u2010inflammatory activities were determined via the caraway iodine method, heat\u2010induced lysis, and denaturation inhibition assays, respectively. The antimicrobial activity was tested using a disc diffusion method, and the antioxidant effects were assessed by six methods. The ethyl acetate extract (HS\u2010EtOAc) showed a stronger \u03b1\u2010amylase inhibitory effect (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 28.70\u00a0\u00b5g\/mL) compared to the reference drug, while the HS\u2010BuOH exerted strong antioxidant activities in CUPRAC (\n                    <jats:italic>A<\/jats:italic>\n                    <jats:sub>0.5<\/jats:sub>\n                    = 3.75\u00a0\u00b5g\/mL) and hydrogen peroxide radical scavenging assays. Additionally, all extracts protected erythrocyte membranes, prevented protein denaturation, and displayed moderate antimicrobial effects. To elucidate the mechanism of action behind these observed bioactivities, drug\u2010likeness, ADMET properties, and molecular docking (\u03b1\u2010amylase, IL\u20101\u03b2, and DNA gyrase) of the isolates were performed. The results revealed high binding affinities associated with promising pharmacokinetic and safety profiles. Furthermore, the stability of the resulting ligand\u2010target complexes was validated through 100\u00a0ns molecular dynamics simulations, with MM\u2010PBSA calculations providing quantitative binding free energies. These results underscore the potential of\n                    <jats:italic>H. sativus<\/jats:italic>\n                    as a valuable source of potential therapeutic agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71711","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:28:31Z","timestamp":1790141311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Multitarget Pharmacological Potential of\n                    <i>Halogeton sativus<\/i>\n                    Secondary Metabolites: An Integrated Experimental and Computational Approach"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6742-5728","authenticated-orcid":false,"given":"Abd Elbasset","family":"Tamersit","sequence":"first","affiliation":[{"name":"Laboratory of Chemistry and Environmental Chemistry (LCCE) Department of Chemistry Faculty of Matter 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