{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:06Z","timestamp":1790542686646,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Borojo, a fruit native to South America, remains to be comprehensively evaluated for its chemical profile. In this study, we isolated and purified nine compounds from borojo. Among these, three were newly identified cyclopentenes (\n                    <jats:bold>BLH\u20101\u2013BLH\u20103<\/jats:bold>\n                    ), one was a novel fused\u2010ring compound (\n                    <jats:bold>BLH\u20104<\/jats:bold>\n                    ), and the remaining five were known compounds (\n                    <jats:bold>BLH\u20105\u2013BLH\u20109<\/jats:bold>\n                    ). To assess their anti\u2010inflammatory potential, we evaluated the compounds in vitro using LPS\u2010stimulated RAW 264.7 murine macrophages. Additionally, we conducted in vivo experiments using zebrafish inflammation models induced by LPS, CuSO\n                    <jats:sub>4<\/jats:sub>\n                    , or tail transection. Our results showed that\n                    <jats:bold>BLH\u20101<\/jats:bold>\n                    ,\n                    <jats:bold>BLH\u20105<\/jats:bold>\n                    , and\n                    <jats:bold>BLH\u20109<\/jats:bold>\n                    significantly inhibited LPS\u2010induced TNF\u2010\u03b1 and IL\u20106 production (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    \u2264\u00a00.05). Additionally,\n                    <jats:bold>BLH\u20101<\/jats:bold>\n                    ,\n                    <jats:bold>BLH\u20102<\/jats:bold>\n                    ,\n                    <jats:bold>BLH\u20104<\/jats:bold>\n                    ,\n                    <jats:bold>BLH\u20106<\/jats:bold>\n                    , and\n                    <jats:bold>BLH\u20107<\/jats:bold>\n                    effectively suppressed neutrophil recruitment in zebrafish triggered by LPS, CuSO\n                    <jats:sub>4<\/jats:sub>\n                    , or physical injury. Further mechanistic investigation in LPS\u2010induced RAW 264.7 cells revealed that\n                    <jats:bold>BLH\u20101<\/jats:bold>\n                    reduced the expression levels of p\u2010I\u03baB\u03b1 and p\u2010STAT3 and inhibited nuclear translocation of NF\u2010\u03baB p65. Taken together, these findings highlight borojo as a promising natural source of anti\u2010inflammatory agents and offer new directions for the discovery of bioactive, food\u2010derived anti\u2010inflammatory compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71712","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:12:53Z","timestamp":1789931573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Chemical Constituents From Borojo and Their Anti\u2010Inflammatory Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Jinying","family":"Ou","sequence":"first","affiliation":[{"name":"Third Level Research Laboratory of State Administration of Traditional Chinese Medicine, Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine Southern Medical University  Guangzhou China"},{"name":"International Joint 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