{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:58:34Z","timestamp":1790542714794,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Essential oils are chemically complex natural products whose biological profiles may vary with volatile composition. This study integrated chemical characterization, antioxidant evaluation,\n                    <jats:italic>Artemia salina<\/jats:italic>\n                    lethality testing, and acetylcholinesterase (AChE) docking to investigate thymol\u2010rich\n                    <jats:italic>Lippia thymoides<\/jats:italic>\n                    Mart. &amp; Schauer (Verbenaceae) essential oil (LTEO) from leaves collected in September 2016 and February 2017. LTEO yield was higher in February 2017 (2.70%) than in September 2016 (2.24%). Overall, 38 constituents were identified, with thymol as the major compound in both samples (32.13% and 30.41%, respectively). The February sample showed higher proportions of monoterpene hydrocarbons, mainly p\u2010cymene, \u03b3\u2010terpinene, and myrcene, whereas the September sample contained higher proportions of oxygenated monoterpenes, thymol acetate, and (E)\u2010caryophyllene. Both samples showed radical\u2010scavenging capacity, with numerically higher Trolox equivalent antioxidant capacity (TEAC) values for September. LTEO induced concentration\u2010dependent lethality in\n                    <jats:italic>A. salina<\/jats:italic>\n                    , with LC\n                    <jats:sub>50<\/jats:sub>\n                    values of 71.08 \u00b1 7.06\u00a0\u00b5g mL\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    for September and 60.06 \u00b1 6.12\u00a0\u00b5g mL\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    for February. Docking indicated that (E)\u2010caryophyllene and thymol acetate had the most favorable dimensionless MolDock Scores. These findings reveal collection\u2010period\u2010related chemical differences and preliminary antioxidant, toxicological, and predictive AChE\u2010interaction profiles. Interactions were dominated by hydrophobic and van der Waals contacts, supporting their interpretation as preliminary molecular evidence requiring future biochemical validation studies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71715","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:23:17Z","timestamp":1789971797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thymol\u2010Rich\n                    <i>Lippia thymoides<\/i>\n                    Mart. &amp; Schauer (Verbenaceae) Essential Oil: Seasonal Chemical Variation, Antioxidant Capacity,\n                    <i>Artemia salina<\/i>\n                    Toxicity, and AChE Docking"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0529-3714","authenticated-orcid":false,"given":"Jorddy Neves","family":"Cruz","sequence":"first","affiliation":[{"name":"Adolpho Ducke Laboratory, Botany Coordination Em\u00edlio Goeldi Museum  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Laboratory of Experimental Pharmacology State University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Biological Sciences Institute Federal University of Para  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e3o Gomes","family":"Silva","sequence":"additional","affiliation":[{"name":"Adolpho Ducke Laboratory, Botany Coordination Em\u00edlio Goeldi Museum  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Antonio Barbosa","family":"Morais","sequence":"additional","affiliation":[{"name":"Adolpho Ducke Laboratory, Botany Coordination Em\u00edlio Goeldi Museum  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7187-9198","authenticated-orcid":false,"given":"Anderson Bentes","family":"de Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pharmacology State University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Rafael Quadros","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pharmacology State University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Postgraduate Program in Biodiversity and Biotechnology (BIONORTE) State University of Par\u00e1 Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2931-4324","authenticated-orcid":false,"given":"Moises","family":"Hamoy","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology and Toxicology of Natural Products, Biological Sciences Institute Federal University of Para  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0640-7496","authenticated-orcid":false,"given":"Eloisa Helena de Aguiar","family":"Andrade","sequence":"additional","affiliation":[{"name":"Adolpho Ducke Laboratory, Botany Coordination Em\u00edlio Goeldi Museum  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1337785"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13071144"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2024.05.021"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.12096"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197\u2010011\u20100251\u20101"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(01)00234\u20103"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13369\u2010026\u201011288\u2010w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27154678"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.20396\/bjos.v20i00.8660219"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1005751"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065\u2010018\u20100484\u20104"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213393"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u2010971236"},{"key":"e_1_2_11_16_1","first-page":"188","article-title":"Lethality 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