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Because these compounds may occur at low concentrations, this study evaluated veratric acid as an alternative phytochemical marker of the cytotoxic activity of an inner bark extract. The hydroethanolic extract was obtained by dynamic maceration, lyophilized, and characterized for total polyphenol content, antioxidant activity, and phytochemical profile. Cytotoxic effects of the extract and veratric acid were assessed in HUVEC, MDA\u2010MB\u2010231, A549, and HepG2 cells. The extract reduced tumor\u2010cell viability more strongly than HUVEC viability under the tested conditions. In contrast, veratric acid at extract\u2010equivalent concentrations did not reduce cell viability. These findings indicate that veratric acid does not account for the cytotoxicity of the extract and is therefore unsuitable as a marker of this biological effect under the conditions evaluated.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71721","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:36:47Z","timestamp":1790141807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Veratric Acid and the Cytotoxic Activity of\n                    <i>Handroanthus impetiginosus<\/i>\n                    Inner Bark Extract: No Association"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-1183","authenticated-orcid":false,"given":"Gabriela Alberto","family":"Gil","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"},{"name":"College of 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