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The antifungal activities of the target compounds against four species of plant\u2010pathogenic fungi were evaluated using in vitro bioassays. Structure\u2013activity relationship (SAR) analysis revealed that the introduction of a trifluoromethyl group imparted superior antifungal activity to the compounds. Notably, compound\n                    <jats:bold>3m<\/jats:bold>\n                    exhibited the most potent inhibitory effect against\n                    <jats:italic>Rhizoctonia solani<\/jats:italic>\n                    , with an EC\n                    <jats:sub>50<\/jats:sub>\n                    value of 0.418\u00a0\u00b5g\/mL, which was significantly better than that of the control agent Fenfuram. Meanwhile, compound\n                    <jats:bold>6b<\/jats:bold>\n                    also demonstrated strong inhibitory activity against\n                    <jats:italic>Fusarium oxysporum<\/jats:italic>\n                    , with an EC\n                    <jats:sub>50<\/jats:sub>\n                    value of 10.723\u00a0\u00b5g\/mL, likewise markedly outperforming Fenfuram. Further in vivo antifungal experiments confirmed that compounds\n                    <jats:bold>3m<\/jats:bold>\n                    and\n                    <jats:bold>6b<\/jats:bold>\n                    achieved satisfactory control efficacy against\n                    <jats:italic>R. solani<\/jats:italic>\n                    and\n                    <jats:italic>F. oxysporum<\/jats:italic>\n                    , respectively. These results indicate promising application prospects for compounds\n                    <jats:bold>3m<\/jats:bold>\n                    and\n                    <jats:bold>6b<\/jats:bold>\n                    . Mechanistic investigations involving microscopic observation, SDH enzyme activity assays, and molecular docking provided further insight into the potential mode of action of\n                    <jats:bold>3m<\/jats:bold>\n                    and\n                    <jats:bold>6b<\/jats:bold>\n                    . The results indicate that compounds\n                    <jats:bold>3m<\/jats:bold>\n                    and\n                    <jats:bold>6b<\/jats:bold>\n                    represent structurally optimized lead candidates for the development of novel, natural product\u2010derived fungicides.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71723","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:00:42Z","timestamp":1789930842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Antifungal Activity of Natural Furan Carboxylic Acid Derivatives as Potential Succinate Dehydrogenase Inhibitors"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0479-4832","authenticated-orcid":false,"given":"Hongxin","family":"Luo","sequence":"first","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science, MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China"},{"name":"Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusen","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchang","family":"Shi","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengna","family":"Dong","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Song","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6029-3242","authenticated-orcid":false,"given":"Zhiqiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optic\u2010electric Sensing and Analytical Chemistry for Life Science, MOE College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6497-462X","authenticated-orcid":false,"given":"Yukun","family":"Qin","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China"},{"name":"Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology Center Qingdao 266237 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