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(Asphodelaceae) is traditionally used in North African ethnomedicine for inflammatory and oxidative stress\u2010related disorders. In this study, the hydroethanolic root extract was investigated by LC\u2013HRMS\/MS, leading to the identification of 58 metabolites, mainly flavonoids, anthraquinones, and cinnamic acid derivatives. Major constituents included luteolin, emodin, luteolin\u20107\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010\u03b2\u2010D\u2010glucoside, subaphyllin (\n                    <jats:italic>N<\/jats:italic>\n                    \u2010\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010feruloylputrescine), and\n                    <jats:italic>N\u2010trans<\/jats:italic>\n                    \u2010feruloyltyramine. The extract showed moderate antiproliferative activity against MDA\u2010MB\u2010231 and PC\u20103 cells, while flow cytometry revealed pronounced apoptosis induction (up to 85%) and significant G0\/G1 cell\u2010cycle arrest. Molecular docking and target prediction suggested multitarget modulation of ER\u03b1, AR, AKT1, CDK2, and BCL\u20102, particularly by aglycone metabolites. ADMET analysis indicated favorable drug\u2010likeness and safety profiles. These findings provide the first mechanistic evidence supporting the multitarget anticancer potential of\n                    <jats:italic>A. tenuifolius<\/jats:italic>\n                    roots and highlight their value as a source of bioactive anticancer scaffolds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71724","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:42:43Z","timestamp":1790142163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Analysis Using LC\u2013MS\/MS and Anticancer Activity of\n                    <i>Asphodelus tenuifolius<\/i>\n                    Roots: Cell Cycle Arrest, Apoptosis, and In Silico Insights"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-2415","authenticated-orcid":false,"given":"Racha Lydia","family":"Bouchouka","sequence":"first","affiliation":[{"name":"Laboratoire 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