{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:10Z","timestamp":1790546170362,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008677","name":"Khulna University","doi-asserted-by":"publisher","award":["KU\/GACELL04(8)\/2000\u2010295"],"award-info":[{"award-number":["KU\/GACELL04(8)\/2000\u2010295"]}],"id":[{"id":"10.13039\/501100008677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Actinodaphne angustifolia<\/jats:italic>\n                    (Lauraceae), traditionally used for treating inflammatory and allergic disorders was investigated for its anti\u2010allergic potential using integrated in vivo and in silico approaches. Safety evaluation in accordance with OECD guidelines confirmed the non\u2010toxic nature of the\n                    <jats:italic>ethanolic<\/jats:italic>\n                    leaf extract. In a toluene 2,4\u2010diisocyanate (TDI)\u2010induced allergic model, the extract reduced allergic symptoms, including sneezing, nasal scratching, and nasal scores, also normalizing elevated white blood cell counts in blood and bronchoalveolar lavage fluid. A marked reduction in serum IgE levels further indicated suppression of hypersensitivity responses, with effects comparable to cetirizine. HPLC analysis revealed a rich polyphenolic profile dominated by (\u2212) epicatechin and rutin hydrate, while GC\u2013MS identified 15 additional bioactive constituents. Molecular docking demonstrated strong binding affinities of these compounds toward key allergic targets, namely histamine H1 receptor, interleukin\u20104, and phospholipase A2, supporting their mechanistic roles in anti\u2010allergic activity. The findings validate the ethnomedicinal relevance of\n                    <jats:italic>A. angustifolia<\/jats:italic>\n                    and highlight its potential as a source of plant\u2010derived anti\u2010allergic agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71727","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:30:41Z","timestamp":1790141441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Allergic Potentials of\n                    <i>Actinodaphne angustifolia<\/i>\n                    : Integrated In Vivo Evaluation and In Silico Analysis of Bioactive Compounds"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-8937","authenticated-orcid":false,"given":"Rabindra Nath","family":"Acharyya","sequence":"first","affiliation":[{"name":"Pharmacy Discipline, Life Science School Khulna University  Khulna Bangladesh"},{"name":"Research Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS)  Tsukuba Ibaraki Japan"},{"name":"Graduate School of Sciences and Technology University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9984-5657","authenticated-orcid":false,"given":"Md. Abid Muktadir","family":"Risha","sequence":"additional","affiliation":[{"name":"Pharmacy Discipline, Life Science School Khulna University  Khulna Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-7804","authenticated-orcid":false,"given":"Novi Dwi Widya","family":"Rini","sequence":"additional","affiliation":[{"name":"Research Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS)  Tsukuba Ibaraki Japan"},{"name":"Graduate School of Sciences and Technology University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4177-9693","authenticated-orcid":false,"given":"Sarita","family":"Manandhar","sequence":"additional","affiliation":[{"name":"Research Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS)  Tsukuba Ibaraki Japan"},{"name":"Graduate School of Sciences and 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