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Qianjinweijingtang (QJWJT), a classical Chinese herbal formula widely used for respiratory diseases, was investigated in this study to compare the anti\u2010RSV efficacy and chemical profiles of its traditional decoction and granule formulation, and to elucidate the underlying mechanisms. Both formulations significantly inhibited RSV infection and its induced inflammatory responses in vitro and in vivo. Further mechanistic analysis revealed that QJWJT acted at an early step of the RSV replication cycle, most likely by interfering with viral entry. UHPLC\u2010Q\u2010Orbitrap HRMS analysis revealed that QJWJT was mainly composed of fatty acids, flavonoids, and phenolic acids, with isoliquiritigenin, quercetin, and gallic acid identified as key bioactive constituents. Moreover, all three compounds bound favorably to both the respiratory syncytial virus fusion (RSV\u2010F) and glycoprotein (RSV\u2010G). Network pharmacology combined with western blotting analysis indicated that QJWJT could inhibit RSV infection by downregulating Hypoxia\u2010Inducible Factor 1\u2010alpha (HIF\u20101\u03b1) expression. In conclusion, this study suggests that the granule formulation has the potential to serve as another option for the traditional decoction, providing a reference for the modernization of Chinese herbal formulas.<\/jats:p>","DOI":"10.1002\/cbdv.71731","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:02:33Z","timestamp":1789930953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Qianjinweijingtang Decoction and Its Granule Inhibit Respiratory Syncytial Virus Infection and the Associated Inflammatory Response"],"prefix":"10.1002","volume":"23","author":[{"given":"Chu\u2010Yi","family":"Liao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment &amp; College of Pharmacy Jinan University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic Medicine Institute of Biomedicine College of Life Science and Technology Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Lan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment &amp; 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College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Nan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment &amp; College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Hua","family":"Deng","sequence":"additional","affiliation":[{"name":"Huizhou No.2 Maternal and Child Health Hospital  Huizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Hai","family":"Ye","sequence":"additional","affiliation":[{"name":"Longchuan County Maternal and Child Health Hospital  Heyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-7463","authenticated-orcid":false,"given":"Zhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic Medicine Institute of Biomedicine College of Life Science and Technology Jinan University  Guangzhou China"},{"name":"Key Laboratory of Innovative Technology Research on Natural Products and Cosmetics Raw Materials  Guangzhou China"},{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine Macau University of Science and Technology  Macau China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; 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