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The results demonstrated that\u00a0the 15\u2010lipoxygenase inhibitory activity of the oil samples ranged from 6% to 80%. Regarding cyclooxygenase (COX) inhibition, while most samples showed negligible activity, the oil produced by Soxhlet extraction inhibited COX\u20101 and COX\u20102 by 38% and 32%, respectively. Similarly, the oil obtained via maceration showed inhibition rates of 25% and 23% for COX\u20101 and COX\u20102, respectively. In the trypsin inhibition assay, the Soxhlet\u2010extracted and macerated oils exhibited 42% and 25% inhibition, respectively. Two market\u2010supplied samples also showed considerable trypsin inhibitory activity, at 39% and 35%. In contrast, none of the sour cherry seed oil samples had a significant effect on chymotrypsin. Gas chromatography with flame ionization detection analysis revealed that linoleic acid, oleic acid, and palmitic acid were the major fatty acid components in all oil samples. Additionally, in silico ADMET profiling and molecular docking studies of the major fatty acids revealed favorable predicted safety profiles and strong binding affinities against the target enzymes, which, alongside the observed in vitro inhibitions, support its potential for further development.<\/jats:p>","DOI":"10.1002\/cbdv.71732","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:04:08Z","timestamp":1789931048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro Anti\u2010Inflammatory Activity of Sour Cherry (\n                    <i>Prunus cerasus<\/i>\n                    L.) Seed Oil and Computational Safety Profiling"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-1456","authenticated-orcid":false,"given":"Tu\u011fba","family":"Aydin","sequence":"first","affiliation":[{"name":"T.R. 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