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The aim of this study was to evaluate\n                    <jats:italic>P. lentiscus<\/jats:italic>\n                    methanol extract (PLME) for its potential antihypoxic and antioxidant activity and to characterize its phytochemical profile. Locomotor and exploratory behavior were investigated using the open\u2010field test (OF). Also, biological activity prediction was performed using the PASS online platform, and molecular docking studies were carried out using AutoDock Vina software. Quantitative investigations revealed high levels of total phenolics (713.952 \u00b1 12.58\u00a0mg GAE\/g extract) and flavonoids (315.821 \u00b1 2.219\u00a0mg QE\/g extract). The HPLC\u2010MS analysis identified phenolic acids and flavonoids. The extract exhibited a dose\u2010dependent increase in scavenging activity and reducing power. PLME could dose\u2010dependently enhance the survival time of mice under normobaric hypoxia and after injection of sodium nitrite. PLME significantly decreased the malondialdehyde (MDA) level compared to the control group. Furthermore, PLME increased the number of squares crossed and the number of rearings in the OF test. PLME constituents exhibited favorable binding affinities with the HIF\u20101\u03b1 and drug\u2010likeness properties. This is the first study to evaluate the antihypoxic efficacy of\n                    <jats:italic>P. lentiscus<\/jats:italic>\n                    L. extract and highlight its significance as a medicinal plant by in vivo and in silico approaches.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71733","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:16:05Z","timestamp":1789971365000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Profiling and Biological Evaluation of\n                    <i>Pistacia lentiscus<\/i>\n                    L. grown in Chlef (Algeria): An Integrated\n                    <i>In Vitro<\/i>\n                    ,\n                    <i>In Vivo<\/i>\n                    , and\n                    <i>In Silico<\/i>\n                    Study"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-2912","authenticated-orcid":false,"given":"Halima","family":"Saiah","sequence":"first","affiliation":[{"name":"Laboratory of Natural Bioresources Faculty of Natural and Life Sciences Hassiba Ben Bouali University  Chlef Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6328-5558","authenticated-orcid":false,"given":"Ali Zineddine","family":"Boumehira","sequence":"additional","affiliation":[{"name":"Research Laboratory in Food Technology and Human Nutrition (LRTANH) National Higher School of Agronomy\u2010ENSA  Algiers Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3866-1629","authenticated-orcid":false,"given":"Wassila","family":"Saiah","sequence":"additional","affiliation":[{"name":"Laboratory of Bioenergetics and Intermediary Metabolism Faculty of Biological Sciences University 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