{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:10Z","timestamp":1790546170723,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Natural lactones represent a promising anti\u2010virulence strategy against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    by targeting quorum\u2010sensing (QS) pathways. In this work, we investigate\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010caprolactone (Capro),\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010octalactone (Octa),\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010decalactone (GDL),\n                    <jats:italic>\u03b4<\/jats:italic>\n                    \u2010decalactone (DDL), and a laboratory\u2010generated lactone mixture (Lx) as modulators of QS\u2010regulated virulence. Treatment with\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010decalactone and engineered lactone formulations significantly downregulated\n                    <jats:italic>rhlR<\/jats:italic>\n                    expression (\u223ctwofold) and suppressed pyocyanin and rhamnolipid production. At 48\u00a0h, lactone exposure reduced extracellular virulence factors by up to 74.81% (pyocyanin) and 49.08% (rhamnolipids), indicating effective disruption of quorum sensing signaling. Collectively, these findings demonstrate that biotransformation\u2010derived lactones attenuate virulence programs in\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , highlighting their potential as quorum sensing inhibitors for managing biofilm\u2010associated infections.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71734","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:39:36Z","timestamp":1790167176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural Lactone\u2010Based Quorum Sensing Inhibitors Attenuate Virulence in\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-8599","authenticated-orcid":false,"given":"Shivani","family":"Chaturvedi","sequence":"first","affiliation":[{"name":"Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry Indian Institute of Technology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0471-2673","authenticated-orcid":false,"given":"Ashutosh","family":"Sharma","sequence":"additional","affiliation":[{"name":"RNA Biology Laboratory, Department of Chemistry Indian Institute of Technology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7708-9353","authenticated-orcid":false,"given":"Tanisha","family":"Singh","sequence":"additional","affiliation":[{"name":"Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry Indian Institute of Technology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibhuti Bhusan","family":"Das","sequence":"additional","affiliation":[{"name":"Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry Indian Institute of Technology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmay","family":"Dutta","sequence":"additional","affiliation":[{"name":"RNA Biology Laboratory, Department of Chemistry Indian Institute of Technology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-3058","authenticated-orcid":false,"given":"Sunil Kumar","family":"Khare","sequence":"additional","affiliation":[{"name":"Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry Indian Institute of Technology  New Delhi India"},{"name":"Department of Biological Sciences Indian Institute of Science Education and Research  Kolkata 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