{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:24Z","timestamp":1790546184669,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Capparis cartilaginea<\/jats:italic>\n                    Decne. (\n                    <jats:italic>C. cartilaginea<\/jats:italic>\n                    ) is traditionally used for the management of inflammatory conditions; however, the contribution of its volatile constituents to these effects remains poorly understood. This study evaluated the anti\u2010inflammatory activity of the essential oil of\n                    <jats:italic>C. cartilaginea<\/jats:italic>\n                    and its major constituents, isopropyl isothiocyanate and 2\u2010methylbutanenitrile, using an in vitro model of lipopolysaccharide (LPS)\u2010induced inflammation in THP\u20101 human macrophages. The essential oil and its main constituents significantly reduced cytokine release and nitric oxide (NO) production compared with LPS\u2010stimulated controls. These effects were associated with modulation of the NLRP3 inflammasome and inhibition of caspase\u20101 activation, partly mediated through MAPK\u2010dependent pathways. In addition, treatment significantly inhibited NF\u2010\u03baB activation and phosphorylation. Overall, these findings demonstrate that the volatile fraction contributes to the anti\u2010inflammatory activity of\n                    <jats:italic>C. cartilaginea<\/jats:italic>\n                    , providing mechanistic support for its traditional use.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71741","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:18:39Z","timestamp":1789971519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory Activity of\n                    <i>Capparis cartilaginea<\/i>\n                    Decne. Essential Oil and Its Main Constituents via Modulation of the NLRP3 Inflammasome"],"prefix":"10.1002","volume":"23","author":[{"given":"Bashaer","family":"Alsharif","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy Umm Al\u2010Qura University  Makkah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadhim","family":"Hante","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute Trinity College Dublin  Dublin Ireland"},{"name":"Faculty of Pharmacy University of Kufa  Kufa Al\u2010Najaf Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-5469","authenticated-orcid":false,"given":"Mar\u00eda Jose","family":"Santos\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute Trinity College Dublin  Dublin Ireland"},{"name":"School of Medicine Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-1787","authenticated-orcid":false,"given":"Fabio","family":"Boylan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nem110"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2018v10i6.22905"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1285243"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2023.100502"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.01095"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11192518"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12061169"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2026.03.029"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16060757"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X221099973"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4078\/jrd.2022.29.3.140"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1267091"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1823724"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010021\u201000740\u20106"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2025.105903"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgag027"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.03.009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1539934"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2023.116424"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031228"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3495"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13436"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13111282"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14130994"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2183026"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"}],"container-title":["Chemistry &amp; 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