{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:51:40Z","timestamp":1791312700220,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Several species within the tribe Cestreae have been implicated in causing hepatotoxicity in livestock.\n                    <jats:italic>Cestrum<\/jats:italic>\n                    ,\n                    <jats:italic>Sessea<\/jats:italic>\n                    , and\n                    <jats:italic>Vestia<\/jats:italic>\n                    are three genera that compose the tribe Cestreae within the family Solanaceae. Herein, we screen 42\n                    <jats:italic>Cestrum<\/jats:italic>\n                    species in addition to 4\n                    <jats:italic>Sessea<\/jats:italic>\n                    species and 1\n                    <jats:italic>Vestia<\/jats:italic>\n                    species for the presence of carboxyparquin and parquin using herbarium specimens by high\u2010performance liquid chromatography\u2010high resolution mass spectrometry (HPLC\u2010HRMS). The toxic principles, carboxyparquin and\/or parquin, were detected in four\n                    <jats:italic>Cestrum<\/jats:italic>\n                    species,\n                    <jats:italic>Sessea brasiliensis<\/jats:italic>\n                    ,\n                    <jats:italic>Sessea vestioides<\/jats:italic>\n                    , and\n                    <jats:italic>Vestia foetida<\/jats:italic>\n                    which are reported to be hepatotoxic to livestock. Additionally, these toxic principles were detected in an additional 18 Cestreae species that have not yet been associated with toxicity in grazing livestock. The presence of carboxyparquin and parquin was sporadic in some species ranging from 25%\u2013100% of the specimens surveyed. No association was found between the phylogenetic relationships of the\n                    <jats:italic>Cestrum<\/jats:italic>\n                    species and the occurrence of carboxyparquin and parquin. Documenting the toxic principles of different species is a critical first step in assessing the poisoning risk of these plants to animals.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71744","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:09:00Z","timestamp":1791310140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection of the Hepatotoxins, Carboxyparquin and Parquin, in\n                    <i>Cestrum<\/i>\n                    ,\n                    <i>Sessea<\/i>\n                    , and\n                    <i>Vestia<\/i>\n                    Species (Solanaceae)"],"prefix":"10.1002","volume":"23","author":[{"given":"Stephen T.","family":"Lee","sequence":"first","affiliation":[{"name":"Poisonous Plant Research Laboratory Agricultural Research Service United States Department of Agriculture  Logan Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Nee","sequence":"additional","affiliation":[{"name":"Missouri Botanical Garden  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8320-4567","authenticated-orcid":false,"given":"Daniel G.","family":"Ubiali","sequence":"additional","affiliation":[{"name":"Setor de Anatomia Patol\u00f3gica (SAP) Instituto de Veterin\u00e1ria Universidade Federal Rural do Rio de Janeiro (UFRuralRJ)  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-7785","authenticated-orcid":false,"given":"Franklin","family":"Riet\u2010Correa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science in the Tropics Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizael","family":"Machado","sequence":"additional","affiliation":[{"name":"Plataforma de Salud Animal (PSA) Instituto Nacional de Investigaci\u00f3n Agropecuaria (INIA)  Tacuaremb\u00f3 Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-113X","authenticated-orcid":false,"given":"Daniel","family":"Cook","sequence":"additional","affiliation":[{"name":"Poisonous Plant Research Laboratory Agricultural Research Service United States Department of Agriculture  Logan Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Toxic Plants of North America","author":"Burrows G. 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M.","year":"1992","journal-title":"Journal of the Chemical Society, Perkin Transactions"},{"key":"e_1_2_10_8_1","first-page":"e07399","volume-title":"Cestrum axillare Hepatotoxicity in Cattle in the Distrito Federal, Goi\u00e1s and Minas Gerais,\" 44","author":"Sousa A. L. V.","year":"2024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tax.574010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102148\u201013\u2010214"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2307\/2992010","article-title":"The Genera Cestrum and Sessea (Solanaceae: Cestreae) in Venezuela","volume":"85","author":"Rojas C. 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R.","year":"2002","journal-title":"INTA EEA"},{"key":"e_1_2_10_17_1","first-page":"183","article-title":"Foco de Intoxicaci\u00f3n por Sessea vestioides en Bovinos","author":"L\u00f3pez Y.","year":"2022","journal-title":"XLIX Jornadas Uruguayas de Buiatr\u00eda"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041\u20100101(02)00239\u20108"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2022.09.005"},{"key":"e_1_2_10_20_1","first-page":"1","volume-title":"Intoxicaci\u00f3n por Duraznillo Negro en el Bovino\"","author":"Riet Alvariza F.","year":"1979"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.toxicon.2021.06.019","article-title":"Endemic Xanthium strumarium Poisoning in Cattle in Flooded Areas of the Araguari River","volume":"200","author":"Machado M.","year":"2021","journal-title":"Toxicon"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c00708"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886\u2010009\u20109637\u20101"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf803468q"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2012.05.029"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2023.107348"},{"key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.toxicon.2016.03.001","article-title":"Studies in Regard to the Classification and Putative Toxicity of Fridericia japurensis (Arrabidaea japurensis) in Brazil","volume":"115","author":"Lima E. 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K.James \u201cPreliminary Study on the Control of RedCestrum \u201d inProceedings of the 32nd New Zealand Weed & Pest Control Conference(New Zealand Weed and Pest Control Society 1979) 289\u2013291.","DOI":"10.30843\/nzpp.1979.32.10722"},{"key":"e_1_2_10_34_1","first-page":"120","article-title":"Plant Toxicity in a Captive Barking Deer (Muntiacus muntjak)","volume":"9","author":"Sharma D.","year":"2008","journal-title":"Intas Polivet"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X0800300420"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2016.04.033"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2019.103921"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf505423h"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71744","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71744","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:09:03Z","timestamp":1791310143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cbdv.71744"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71744","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71744"}}