{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:52:21Z","timestamp":1791287541974,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Lippia alba<\/jats:italic>\n                    is an aromatic plant whose essential oils (EOs) have been characterized as promising antimicrobial agents. It has been established that\n                    <jats:italic>L. alba<\/jats:italic>\n                    chemotypes are influenced by both genetic and environmental factors. We evaluated the EO yield, composition, and antimicrobial activity of 20 genotypes from a sympatric genetically diverse population of\n                    <jats:italic>L. alba<\/jats:italic>\n                    . These analyses were performed over two seasonal periods, during which climate data were collected and leaf nutrients assessed. EO yield was highest on average during summer, although genotype\u2010specific patterns were observed. Gas chromatography\u2013mass spectrometry identified 47 compounds, which 27 were observed to be shared among the 20 genotypes. A total of 10 of the 20 genotypes studied had seasonal shifts in predominant constituents. Minimum inhibitory concentration (MIC) assays showed high antimicrobial activity in summer samples, followed by spring, despite being more effective in the first seasonal data. Micronutrients data suggest that nutrient variation may be associated with changes in essential oil composition. Though exploratory, these results highlight the importance of considering both genotype and harvest season for EO standardization in antimicrobial phytotherapy and other potential applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71745","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:07:46Z","timestamp":1791284866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seasonal Variation of Essential Oils Composition in a Genetically Diverse Population of\n                    <i>Lippia alba<\/i>\n                    and Its Influence on Antibacterial Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Marina Er\u00ea Almeida Hummel Pimenta","family":"Santos","sequence":"first","affiliation":[{"name":"Centro De P&amp;D De Recursos Gen\u00e9ticos Vegetais Instituto Agron\u00f4mico (IAC)  Campinas Sao Paulo Brazil"},{"name":"P\u00f3s\u2010Gradua\u00e7\u00e3o Em Agricultura Tropical e Subtropical Instituto Agron\u00f4mico (IAC)  Campinas Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8862-1942","authenticated-orcid":false,"given":"Taila Gomes","family":"Botelho","sequence":"additional","affiliation":[{"name":"Centro De P&amp;D De Recursos Gen\u00e9ticos Vegetais Instituto Agron\u00f4mico (IAC)  Campinas Sao Paulo Brazil"},{"name":"P\u00f3s\u2010Gradua\u00e7\u00e3o Em Agricultura Tropical e Subtropical Instituto Agron\u00f4mico (IAC)  Campinas Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Delarmelina","sequence":"additional","affiliation":[{"name":"Centro Pluridisciplinar de Pesquisas Qu\u00edmicas, Biol\u00f3gicas e Agr\u00edcolas (CPQBA) Universidade Estadual de Campinas (UNICAMP)  Paul\u00ednia Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter Jos\u00e9","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Centro De P&amp;D De Recursos Gen\u00e9ticos Vegetais Instituto Agron\u00f4mico (IAC)  Campinas Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Cristina Teixeira","family":"Duarte","sequence":"additional","affiliation":[{"name":"Centro Pluridisciplinar de Pesquisas Qu\u00edmicas, Biol\u00f3gicas e Agr\u00edcolas (CPQBA) Universidade Estadual de Campinas (UNICAMP)  Paul\u00ednia Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8270-4308","authenticated-orcid":false,"given":"Marcia Ortiz Mayo","family":"Marques","sequence":"additional","affiliation":[{"name":"Centro De P&amp;D De Recursos Gen\u00e9ticos Vegetais Instituto Agron\u00f4mico (IAC)  Campinas Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-6605","authenticated-orcid":false,"given":"Jorge Maur\u00edcio Costa","family":"Mondego","sequence":"additional","affiliation":[{"name":"Centro De P&amp;D De Recursos Gen\u00e9ticos Vegetais Instituto Agron\u00f4mico (IAC)  Campinas Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.17179\/excli2025\u20108439"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11070979"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1668594"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.05.033"},{"key":"e_1_2_10_6_1","first-page":"35","volume-title":"Produtos Naturais Bioativos","author":"Ming L. C.","year":"2016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajb2.1443"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.04.028"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709\u2010021\u201001636\u2010y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.15517\/rbt.v68i1.39153","article-title":"Essential Oils Biological Activity of the Shrub Lippia alba (Verbenaceae)","volume":"68","author":"Ortega\u2010Cuadros M.","year":"2020","journal-title":"Revista de Biolog\u00eda Tropical"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709\u2010023\u201001890\u20102"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/horticulturae10090925"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2024.101287"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jarmap.2021.100297"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scienta.2015.09.046"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1684624"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102672.2009.04597.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02783"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30214236"},{"key":"e_1_2_10_20_1","unstructured":"P. Y.Yamamoto \u201cIntera\u00e7\u00e3o Gen\u00f3tipo X Ambiente na Produ\u00e7\u00e3o e Composi\u00e7\u00e3o de \u00d3leos Essenciais deLippia alba(Mill.) N. E. Br. 71f. Thesis (Mestrado em Melhoramento Gen\u00e9tico Vegetal)\u2014P\u00f3s\u2010Gradua\u00e7\u00e3o\u2014IAC. Campinas SP Brazil \u201d (2006)."},{"key":"e_1_2_10_21_1","unstructured":"D. S.Rocha \u201cDiverg\u00eancia Gen\u00e9tica e Qu\u00edmica em germoplasma deLippia albaUtilizando Marcadores Microssat\u00e9lites e \u00d3leo Essencial. 72 f. Thesis (Mestrado em AgriculturaTropical e Subtropical)\u2014P\u00f3s\u2010Gradua\u00e7\u00e3o\u2014IAC. Campinas SP Brazil \u201d (2014)."},{"key":"e_1_2_10_22_1","volume-title":"Caracteriza\u00e7\u00e3o de Variabilidade Gen\u00e9tica, \u00d3leos Essenciais e Suas Atividades Antimicrobianas em Germoplasma de Lippia alba","author":"Santos M. E. A. H. 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