{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:14Z","timestamp":1790546174661,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Species of the genus\n                    <jats:italic>Jacaranda<\/jats:italic>\n                    are often cited for their significant pharmacological potential, including antitumor and antioxidant activity. Therefore, this study aimed to evaluate the antioxidant activity of hot and cold extraction methods for methanolic extracts of leaves and twigs of the species\n                    <jats:italic>Jacaranda caroba<\/jats:italic>\n                    ,\n                    <jats:italic>Jacaranda mimosifolia<\/jats:italic>\n                    , and\n                    <jats:italic>Jacaranda oxyphylla<\/jats:italic>\n                    , as well as their cytotoxic capacities. Leaves and twigs were dried and subjected to extraction with hexane, chloroform, and methanol to obtain crude extracts. For antioxidant activity, the cold extraction of\n                    <jats:italic>J. mimosifolia<\/jats:italic>\n                    twigs yielded the best results, while the hot extraction provided the best results for\n                    <jats:italic>J. caroba<\/jats:italic>\n                    leaf extract. Regarding cytotoxic activity against THP\u20101 and PBMC cell lines, the chloroform and methanolic extracts from\n                    <jats:italic>J. mimosifolia<\/jats:italic>\n                    twigs exhibited the best selectivity indices (SI = 5.17 and SI = 5.50, respectively), results superior to those of the standard drug Cytarabine (SI = 4.4).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71746","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:40:47Z","timestamp":1790142047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Total Phenolic Content, Antioxidant and Cytotoxic Activity of Three\n                    <i>Jacaranda<\/i>\n                    Species (Bignoniaceae)"],"prefix":"10.1002","volume":"23","author":[{"given":"Eliane Cristina","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Chemistry Universidade Federal dos Vales do Jequitinhonha e Mucuri  Diamantina Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abra\u00e3o Jos\u00e9 Silva","family":"Viana","sequence":"additional","affiliation":[{"name":"Integrated Multi\u2010User Research Laboratory Universidade Federal dos Vales do Jequitinhonha e Mucuri  Diamantina Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Victor Mendon\u00e7a","family":"Filho","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Universidade Federal dos Vales do Jequitinhonha e Mucuri  Diamantina Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson Cotta","family":"Bodevan","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Universidade Federal dos Vales do Jequitinhonha e Mucuri  Diamantina Minas Gerais 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8562-8689","authenticated-orcid":false,"given":"Adriano de Paula","family":"Sabino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5369-5147","authenticated-orcid":false,"given":"Roqueline Rodrigues","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry Universidade Federal dos Vales do Jequitinhonha e Mucuri  Diamantina Minas Gerais 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