{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:59:23Z","timestamp":1790837963552,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Rubia cordifolia<\/jats:italic>\n                    L. is an important Himalayan medicinal plant valued for its diverse therapeutic properties. The present study investigated the influence of altitude, habitat conditions, and edaphic factors on nutritional composition, phytochemicals, and antioxidant activity of\n                    <jats:italic>R. cordifolia<\/jats:italic>\n                    populations collected from different habitats (open grassy, shady, and moist shady) in the western Himalaya. Significant variations (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u2264\u00a00.05) were observed in edaphic factors, nutritional components and phytochemicals, antinutritional factors and antioxidant activities. High\u2010altitude populations showed higher accumulation of total phenolics (52.59\u00a0mg GAE\/g dw), flavonoids (120.84\u00a0mg QE\/g dw), alizarin (2.68\u00a0mg\/g dw), and mollugin (23.77\u00a0mg\/g dw). Correlation analysis revealed a significant positive correlation of altitude with phenolics, flavonoids, alizarin, catechin, amino acids, and thiamine. Whereas, soil pH demonstrated negative correlations with several metabolites. In contrast, altitude was negatively correlated (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u2264\u00a00.01) with salicylic acid in leaves and stems and tannin content in roots. Moist shady habitats showed greater accumulation of nutritional and bioactive compounds compared with open grassy and shady habitats. The results suggest that altitude, habitat conditions, and soil factors collectively regulate metabolic plasticity and antioxidant potential in\n                    <jats:italic>R. cordifolia<\/jats:italic>\n                    . High\u2010altitude populations occuring in moist shady habitat may presents valuable germplasm for conservation, cultivation, and pharmaceutical applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71747","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:39:59Z","timestamp":1790836799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Environmental Drivers of Metabolic Plasticity in\n                    <i>Rubia cordifolia<\/i>\n                    From the Western Himalaya: Implications for Phytochemical Diversity and Antioxidant Potential"],"prefix":"10.1002","volume":"23","author":[{"given":"Deepti","family":"Tiwari","sequence":"first","affiliation":[{"name":"Centre For Biodiversity Conservation and Management G. B. Pant National Institute of Himalayan Environment, Kosi\u2010Katarmal Almora Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-2878","authenticated-orcid":false,"given":"Sandeep","family":"Rawat","sequence":"additional","affiliation":[{"name":"G. B. Pant National Institute of Himalayan Environment Sikkim Regional Centre  Gangtok Sikkim India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-0517","authenticated-orcid":false,"given":"Veena","family":"Pandey","sequence":"additional","affiliation":[{"name":"Division of Environment Science Indian Agriculture Research Institute New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod C.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Wildlife Institute of India, Chandrabani  Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0063-9050","authenticated-orcid":false,"given":"Indra D.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Centre For Biodiversity Conservation and Management G. B. Pant National Institute of Himalayan Environment, Kosi\u2010Katarmal Almora Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-0609","authenticated-orcid":false,"given":"R. C.","family":"Sundriyal","sequence":"additional","affiliation":[{"name":"Department of Forestry and Natural Resources HNB Garhwal University Srinagar, Garhwal Uttarakhand India"},{"name":"Sparsh Himalaya University  Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201037495\u20101"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100345"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010016\u20102039\u20102"},{"key":"e_1_2_11_5_1","first-page":"1","volume-title":"IOP Conference Series: Earth and Environmental Science","author":"Setyawati A.","year":"2021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200900041"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.egg.2017.06.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/0129504910378059250714100323"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/0129504910378059250714100323"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.965390"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v10i6.4514"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5958\/0975\u20106892.2021.00058.7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/0118722083359338250611055647"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3742\/OPEM.2009.9.1.001"},{"key":"e_1_2_11_15_1","first-page":"28","article-title":"Development of Anti\u2010acne Gel Formulation of Anthraquinones Rich Fraction From Rubia Cordifolia (Rubiaceae)","volume":"4","author":"Khan K.","year":"2011","journal-title":"International Journal of Applied Research in Natural Products"},{"key":"e_1_2_11_16_1","first-page":"330","article-title":"Standardization of Majith (Rubia cordifolia Linn.)","volume":"10","author":"Siddiqui A.","year":"2011","journal-title":"Indian Journal of Traditional Knowledge"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201022631\u2010z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijp.IJP_418_17"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.10.019"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S338548"},{"key":"e_1_2_11_21_1","first-page":"2720","article-title":"Rubia Cordifolia\u2010a Review on Pharmacognosy and Phytochemistry","volume":"7","author":"Verma A.","year":"2016","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catena.2021.105667"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/02827581.2020.1871065"},{"key":"e_1_2_11_24_1","first-page":"117","article-title":"Physical Properties of Soils in Relation to Forest Composition in Moist Temperate Valley Slopes of the Central Western Himalaya","volume":"26","author":"Sharma C. 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