{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:47:51Z","timestamp":1792068471470,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2020C02034"],"award-info":[{"award-number":["2020C02034"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Given the global surge in obesity, this study evaluated artichoke polyphenols (APs) as potential functional agents against obesity\u2010related hepatic lipid accumulation by elucidating their chemical composition and underlying mechanisms. Semi\u2010quantitative HPLC\u2010MS analysis revealed that 1,4\u2010dicaffeoylquinic acid and chlorogenic acid constituted 60\u201380% of the total polyphenolic peak areas, with inner bract polyphenols (IBAPs) exhibiting higher purity and phenolic acid content than outer bract polyphenols (OBAPs). In an oleic acid\u2010induced high\u2010fat HepG2 cell model, APs at non\u2010cytotoxic concentrations dose\u2010dependently and significantly reduced intracellular lipid droplet accumulation, triglyceride, and total cholesterol levels. Mechanistically, APs were correlated with activation of the AMPK signaling pathway, markedly upregulating AMPK\u03b1, phosphorylated AMPK\u03b1, and CPT1A, while concurrently downregulating FABP4, and PPAR\u03b3. These findings suggest that artichoke bract polyphenols are associated with alleviation of hepatic lipid accumulation, potentially through coordinated modulation of PPAR and AMPK pathways that correlate with enhanced mitochondrial fatty acid oxidation and reduced de novo lipogenesis, highlighting their potential as natural functional agents that warrant further investigation for managing obesity\u2010related metabolic disorders.<\/jats:p>","DOI":"10.1002\/cbdv.71750","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:55:33Z","timestamp":1792065333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artichoke Polyphenols Rich in 1,4\u2010Dicaffeoylquinic Acid Regulate Lipid Metabolism via the PPAR and AMPK Pathways to Alleviate Hepatic Lipid Accumulation"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7762-8929","authenticated-orcid":false,"given":"Wenyang","family":"Tao","sequence":"first","affiliation":[{"name":"Institute of Food Science Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Food Science Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanqin","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Food Science Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Food Science Zhejiang Academy of Agricultural Sciences  Hangzhou Zhejiang 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