{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:14Z","timestamp":1790546174687,"version":"4.1.0"},"reference-count":98,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Byrsonima crassifolia<\/jats:italic>\n                    is a fruit\u2010bearing species widely distributed across tropical regions of the Americas with potential health applications. This review updates the knowledge base on its traditional uses, phytochemicals, and pharmacological activities to support future research.\u200b Native communities employ it as a key food and artisanal resource. As a medicinal plant, it has a history of treating diarrhea, diabetes, inflammation, and other conditions.\u200b Extracts and fractions, mainly from leaves and fruits, reveal numerous bioactive compounds, particularly non\u2010flavonoid polyphenols, flavonoids, and terpenoids. In vivo and in vitro evidence shows convergence between traditional medicine and a range of pharmacological activities, including antimicrobial, anti\u2010inflammatory, hypoglycemic, and gastroprotective effects; other reports indicate antioxidant, neuromodulatory, photoprotective, chemopreventive, and antitumor properties.\u200b Various studies link these pharmacological findings to the antioxidant profile of polyphenols identified in the species. Additionally, individual terpenoids isolated from seeds show promising effects on infection, inflammation, and glycemic control.\u200b Collectively, these findings indicate that the use of\n                    <jats:italic>B. crassifolia<\/jats:italic>\n                    and its bioactive compounds has a scientific basis. However, future research must advance in extract standardization, chemical marker quantification, molecular mechanism exploration, toxicity testing, and clinical trials to validate its therapeutic potential.\u200b\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71756","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:39:52Z","timestamp":1790537992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Byrsonima crassifolia<\/i>\n                    : Ethnobotany, Phytochemistry, and Pharmacology \u2013 An Update"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-6131","authenticated-orcid":false,"given":"Jo\u00e3o de Jesus","family":"Oliveira Junior","sequence":"first","affiliation":[{"name":"Graduate Program in Biotechnology Northeast Biotechnology Network (RENORBIO) Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-5647","authenticated-orcid":false,"given":"D\u00e9bora Luana Ribeiro","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Special Coordination of Physiological Sciences and Pathology Center for Biological and Health Sciences Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-5888","authenticated-orcid":false,"given":"Marilene Oliveira da Rocha","family":"Borges","sequence":"additional","affiliation":[{"name":"Special Coordination of Physiological Sciences and Pathology Center for Biological and Health Sciences Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_14_2_1","article-title":"Plantas Medicinais com Potencial Anti\u2010idade: Uma Revis\u00e3o de Literatura","volume":"12","author":"Soares C. 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