{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:12Z","timestamp":1790546172290,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The objective was to evaluate the essential oil (EO) from\n                    <jats:italic>Croton sertanejus<\/jats:italic>\n                    leaves against\n                    <jats:italic>Aedes aegypti<\/jats:italic>\n                    , analyzing spatial repellency (SR), topical effective concentration (EC), EC protection time, oviposition deterrence, and preliminary toxicity in\n                    <jats:italic>Mus musculus<\/jats:italic>\n                    . Additionally, the chemical composition of the oil was characterized. Results showed a significant SR of 0.2 starting from 1\u00a0mg\/cm\n                    <jats:sup>2<\/jats:sup>\n                    . The ECs required to repel 50% and 99% of the mosquitoes were 3 and 109\u00a0mg\/cm\n                    <jats:sup>2<\/jats:sup>\n                    , respectively. The EC of 109\u00a0mg\/cm\n                    <jats:sup>2<\/jats:sup>\n                    provided 64.8% protection against landings within 360\u00a0min and 100% protection against blood\u2010feeding for 150\u00a0min. The EO significantly reduced oviposition at water volumes of 20\u00a0mL (beginning at 2.5\u00a0mg\/mL) and 500\u00a0mL (beginning at 0.005\u00a0mg\/mL); however, no significant effect was observed at 1000\u00a0mL. No mortality occurred in\n                    <jats:italic>Mus musculus<\/jats:italic>\n                    . However, at a dose of 2000\u00a0mg\/kg, a significant reduction in brain weight was observed, while at 300\u00a0mg\/kg, an increase in lung and kidney weights occurred. At 2000\u00a0mg\/kg, there were also elevated levels of aspartate aminotransferase and alanine aminotransferase, alongside a reduction in creatinine. Regarding the chemical composition, eucalyptol was the main component. Therefore, these findings underscore the need for further validation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71759","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:52:27Z","timestamp":1790538747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Composition and Biological Activities of\n                    <i>Croton sertanejus<\/i>\n                    Essential Oil Against\n                    <i>Aedes aegypti<\/i>\n                    and Preliminary\n                    <i>Toxicity<\/i>\n                    in\n                    <i>Mus Musculus<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7637-2642","authenticated-orcid":false,"given":"Daniel Lobo","family":"Sousa","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Biology State University of Southwestern Bahia (UESB)  Itapetinga BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgana Maria do Carmo","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Environmental Sciences State University of Southwestern Bahia (UESB)  Itapetinga BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo Carlos Dantas da","family":"Cruz","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Department of Antibiotics Federal University of Pernambuco  Recife PE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivone Antonia de","family":"Souza","sequence":"additional","affiliation":[{"name":"Pharmacology Department of Antibiotics Federal University of Pernambuco  Recife PE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4210-7215","authenticated-orcid":false,"given":"Rosilene Aparecida de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Chemistry Department of Exact and Technological Sciences State University of Santa Cruz  Salobrinho BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6573-6594","authenticated-orcid":false,"given":"D\u00e9bora Cardoso da","family":"Silva","sequence":"additional","affiliation":[{"name":"Veterinary Sciences Research Center in Applied Chemistry Department of Exact and Natural Sciences (DCEN)\/(UESB)  Itapetinga BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-002X","authenticated-orcid":false,"given":"Simone Andrade","family":"Gualberto","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center in Applied Chemistry Department of Exact and Natural Sciences (DCEN)\/(UESB)  Itapetinga BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0388-1208","authenticated-orcid":false,"given":"Eduardo Carvalho","family":"Lira","sequence":"additional","affiliation":[{"name":"Physiology Department of Physiology and Pharmacology Federal University of Pernambuco Cidade Universit\u00e1ria  Recife PE Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana\u00edna Silva de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Biochemistry, Department of Exact and Natural Sciences (DCEN)\/(UESB)  Itapetinga BA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Minist\u00e9rio da Sa\u00fade.Monitoramento das Arboviroses e Balan\u00e7o de Encerramento do Comit\u00ea de Opera\u00e7\u00f5es de Emerg\u00eancia (COE) Dengue e Outras Arboviroses 2024 55 no.11(2024):2\u201332. 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