{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:12Z","timestamp":1790546172885,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The Allchar Mining Area (North Macedonia) is an extreme metalliferous environment enriched in Tl, As and Sb that supports diverse endemic metallophytes. This study investigates metabolic profiles in selected species through integrated analysis of polyphenols (HPLC\/DAD\/MS\n                    <jats:sup>n<\/jats:sup>\n                    ) and biogenic volatile organic compounds (BVOCs, headspace GC\u2013MS). A total of 78 polyphenols and 123 volatile compounds were identified.\n                    <jats:italic>Knautia caroli\u2010rechingeri<\/jats:italic>\n                    and\n                    <jats:italic>Centaurea leucomalla<\/jats:italic>\n                    were dominated by caffeoylquinic acid derivatives, in which reached 405.40\u00a0mg\/g dry herb in\n                    <jats:italic>K. caroli\u2010rechingeri<\/jats:italic>\n                    .\n                    <jats:italic>Thymus thracicus<\/jats:italic>\n                    var.\n                    <jats:italic>alsarensis<\/jats:italic>\n                    showed a distinct profile rich in rosmarinic and salvianolic acids, whereas Tl\u2010hyperaccumulating\n                    <jats:italic>Viola<\/jats:italic>\n                    species were characterized by flavone and flavonol glycosides together with a markedly reduced diversity of phenolic acids. BVOC profiles also differed markedly among species, including terpene\u2010rich profiles in\n                    <jats:italic>Thymus<\/jats:italic>\n                    , aldehyde\u2010dominated compositions in\n                    <jats:italic>Knautia<\/jats:italic>\n                    and\n                    <jats:italic>Centaurea<\/jats:italic>\n                    , and non\u2010terpenoid\u2010enriched profiles in\n                    <jats:italic>Viola<\/jats:italic>\n                    species. Multivariate analysis confirmed species\u2010specific metabolic patterns and significant concordance between polyphenolic and BVOC profiles (Mantel\n                    <jats:italic>\u03c1<\/jats:italic>\n                    \u00a0=\u00a00.72 and\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.008), while no significant association with reported Tl accumulation was observed. Metabolomic and metal accumulation patterns highlight species\u2010specific biochemical characteristics associated with life in metalliferous habitats.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71761","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:42:07Z","timestamp":1790538127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyphenolic and Biogenic Volatile Organic Compound Profiles of Endemic Metallophytes From the Thallium\u2010Rich Allchar Mining Area"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8007-2949","authenticated-orcid":false,"given":"Marinela","family":"Cvetanoska","sequence":"first","affiliation":[{"name":"Institute of Chemistry, Faculty of Natural Sciences and Mathematics Ss. Cyril and Methodius University in Skopje  Skopje Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4232-3759","authenticated-orcid":false,"given":"Marina","family":"Stefova","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Faculty of Natural Sciences and Mathematics Ss. Cyril and Methodius University in Skopje  Skopje Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-1040","authenticated-orcid":false,"given":"Katerina Ba\u010deva","family":"Andonovska","sequence":"additional","affiliation":[{"name":"Research Centre for Environment and Materials Macedonian Academy of Sciences and Arts  Skopje The Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0780-0660","authenticated-orcid":false,"given":"Jasmina Petreska","family":"Stanoeva","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Faculty of Natural Sciences and Mathematics Ss. Cyril and Methodius University in Skopje  Skopje Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Allchar Mineral Assemblage","volume":"15","author":"Boev B.","year":"2001","journal-title":"Geologica Macedonica"},{"key":"e_1_2_8_3_1","first-page":"199","article-title":"Territorial Division of the Endemics in the SR Macedonia and the Problem of Their Vulnerability","volume":"14","author":"Micevski K.","year":"1987","journal-title":"Academy of Sciences and Arts of Bosnia and Herzegovina, Special Editions, Section of Natural Sciences"},{"issue":"4","key":"e_1_2_8_4_1","first-page":"523","article-title":"Phenolic Compounds and Their Antioxidant Activity in Plants Growing Under Heavy Metal Stress","volume":"15","author":"Michalak A.","year":"2006","journal-title":"Polish Journal of Environmental Studies"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11120\u2010020\u201000768\u20101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28093921"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2298\/BOTSERB2202161J"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2013.11.011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2020.00359"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/217037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592324.2018.1460048"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-4470-7_2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10876\u2010022\u201002276\u20109"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5643"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14010074"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmpp.2024.102383"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/anbo.2000.1271"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28176322"},{"issue":"3","key":"e_1_2_8_19_1","first-page":"669","article-title":"Effect of Heavy Metals (Hg, As and La) on Biochemical Constituents of Spinacia oleracea","volume":"8","author":"Ahmed N.","year":"2019","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10646\u2010022\u201002607\u20106"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1995425514020073"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.5376\/mpr.2015.05.0004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112828"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15226514.2013.783551"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcaf166"},{"key":"e_1_2_8_26_1","first-page":"33","article-title":"Bioaccumulation of Some Toxic Elements by Endemic Plant Species Onobrychis Degenii D\u00f6rfler, Knautia Caroli\u2010Rechingeri Micev. and Centaurea Kavadarensis Micev. 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