{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:14Z","timestamp":1790546174597,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In our study, pH\u2010responsive poly(acrylic acid)\u2010Cu\n                    <jats:sup>2+<\/jats:sup>\n                    hybrid nanoflowers (PAA@Cu\n                    <jats:sup>2+<\/jats:sup>\n                    hNFs) were fabricated by using poly(acrylic acid) and Cu\n                    <jats:sup>2+<\/jats:sup>\n                    ions in phosphate\u2010buffered saline solution (PBS). For comparison, pure copper phosphate nanoflowers (Cu NFs) were fabricated. Synthesized PAA@Cu\n                    <jats:sup>2+<\/jats:sup>\n                    hNFs and Cu NFs were characterized using SEM, EDX, XRD, FTIR, BET, zeta potential, and DLS measurements. Within the pH range of 6\u20139, PAA@Cu\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    hNFs exhibit a spherical, flower\u2010like porous morphology, with the pH 9 sample showing a more compact, uniform structure and more homogeneous interpetal pores than those at other pH values. Then, hemoglobin (Hb) adsorption studies were also performed using PAA@Cu\n                    <jats:sup>2+<\/jats:sup>\n                    hNFs and Cu NFs across various parameters, including pH, Hb concentration, ionic strength, temperature, and time. At pH 7, the highest Hb adsorption capacities of PAA@Cu\n                    <jats:sup>2+<\/jats:sup>\n                    hNFs and Cu NFs were calculated as 961.98 and 94.23\u00a0mg\/g, respectively. The desorption studies of Hb from the synthesized nanoflowers were performed in an acetate buffer solution including NaCl. The desorption yields of Hb for PAA@Cu\n                    <jats:sup>2+<\/jats:sup>\n                    hNFs and Cu NFs were calculated as 96.1% and 95.8%, respectively. Then, the reusability of the synthesized nanoflowers for Hb adsorption was evaluated over five cycles. These results suggest that PAA@Cu\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    hNFs are suitable for Hb separation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71762","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:08:20Z","timestamp":1790539700000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemoglobin Adsorption\/Desorption Studies of New Generation Stimuli Responsive Polyacrylic Acid\u2010Cu\n                    <sup>2+<\/sup>\n                    Hybrid Nanoflowers (PAA@Cu\n                    <sup>2+<\/sup>\n                    hNFs)"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0833-3224","authenticated-orcid":false,"given":"Merve","family":"Durmus","sequence":"first","affiliation":[{"name":"Spectroscopy@IKU, IKU\u2010SPECTRA Molecular Sciences and Spectroscopy Applied Research Center, Istanbul Kultur University  Istanbul T\u00fcrkiye"},{"name":"Department of Common Courses Rectorate, Istanbul Kultur University  Istanbul T\u00fcrkiye"},{"name":"Chemistry, Graduate School of Natural and Applied Sciences, Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-5198","authenticated-orcid":false,"given":"Nalan","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b21511"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2018.07.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.202000129"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.80"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR05446D"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2016.08.059"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.110354"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904\u2010024\u201003268\u20100"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129075"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202401352"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c00703"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c01425"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2025.344685"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202002242"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13051241"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111020"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2022.132853"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.12.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.03.096"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CC02729B"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2018.02.011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01030H"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.24018\/ejchem.2022.3.1.86"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10102051"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202104131"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4031059"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hybadv.2024.100178"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202015790"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2018.07.019"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2020.102254"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00289\u2010021\u201003557\u20105"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2018.11.130"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14061259"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2009.02.061"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/C000465K"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051\u2010012\u20101353\u2010z"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2010.02.041"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA10423J"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.15671\/hjbc.921540"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100683"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/10601325.2015.1050628"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00289\u2010021\u201003973\u20107"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20102697(76)90527\u20103"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/am502757e"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742\u20106596\/1285\/1\/012023"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00911K"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CP08854F"},{"key":"e_1_2_10_49_1","unstructured":"H. F.BunnandB. G.Forget Hemoglobin: Molecular Genetic and Clinical Aspects (W. B. Saunders Company Philadelphia PA 1986) ISBN 0\u20107216\u20102181\u20103."},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00396\u2010013\u20103103\u2010x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/1616\u20105195(20010601)1:4<157::AID\u2010MABI157>3.0.CO;2\u2010S"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.12.036"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109673(01)93202\u20109"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583500005369"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/43.10.2014a"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1260\/026361705775373279"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2016.1233112"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2019.144215"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2020.108248"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01793"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2JM14329A"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA12457K"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201701479"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2004.06.008"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB01476E"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2017.06.006"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eti.2020.100798"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.71762","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.71762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:57:16Z","timestamp":1790542636000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.71762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":66,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cbdv.71762"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.71762","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71762"}}