{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:18Z","timestamp":1790546178436,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012046","name":"Vietnam Academy of Science and Technology","doi-asserted-by":"publisher","award":["T\u0110\u0110TMT.05\/24\u201026"],"award-info":[{"award-number":["T\u0110\u0110TMT.05\/24\u201026"]}],"id":[{"id":"10.13039\/100012046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two new cytotoxic sulfated compounds, cinerascensosides A and B (\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    ), alongside three described triterpene glycosides, holothurins A (\n                    <jats:bold>3<\/jats:bold>\n                    ), B (\n                    <jats:bold>4<\/jats:bold>\n                    ), and B\n                    <jats:sub>3<\/jats:sub>\n                    (\n                    <jats:bold>5<\/jats:bold>\n                    ), were separated from the sea cucumber\n                    <jats:italic>Holothuria cinerascens<\/jats:italic>\n                    . Their structures and absolute configurations were established through extensive spectroscopic analysis, DP4+ probability calculation, and ECD calculations. Furthermore, probable biosynthetic pathways of\n                    <jats:bold>1\u22125<\/jats:bold>\n                    were suggested. Among them, compound\n                    <jats:bold>4<\/jats:bold>\n                    exhibited the most potent cytotoxicity against the HepG2 cell line (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a02.60 \u00b5M), followed by compound\n                    <jats:bold>3<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a02.80 \u00b5M). Compound\n                    <jats:bold>2<\/jats:bold>\n                    displayed cytotoxicity on the KB and SK\u2010LU\u20101 cell lines (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a09.28 and 9.49 \u00b5M, respectively), whereas compound\n                    <jats:bold>3<\/jats:bold>\n                    exhibited potent activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a02.48 and 2.98 \u00b5M). Computational analyses, including molecular docking, network pharmacology, and molecular dynamics (MDs) simulations, collectively suggest a potential mechanism of action underlying the observed cytotoxic activity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71763","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:19:53Z","timestamp":1790345993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cinerascensosides A and B, Two New Cytotoxic Sulfated Saponins From the Sea Cucumber\n                    <i>Holothuria cinerascens<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Tran Thi Hong","family":"Hanh","sequence":"first","affiliation":[{"name":"Institute of Chemistry (ICH) Vietnam Academy of Science and Technology (VAST) Nghia Do  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninh Thi","family":"Ngoc","sequence":"additional","affiliation":[{"name":"Institute of Chemistry (ICH) Vietnam Academy of Science and Technology (VAST) Nghia Do  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi","family":"Vien","sequence":"additional","affiliation":[{"name":"Institute of Chemistry (ICH) Vietnam Academy of Science and Technology (VAST) Nghia Do  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Xuan","family":"Cuong","sequence":"additional","affiliation":[{"name":"Institute of Chemistry (ICH) Vietnam Academy of Science and Technology (VAST) Nghia Do  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Viet","family":"Ha","sequence":"additional","affiliation":[{"name":"Institute of Oceanography VAST  Nha Trang, Khanhhoa Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Hoai","family":"Nam","sequence":"additional","affiliation":[{"name":"Institute of Chemistry (ICH) Vietnam Academy of Science and Technology (VAST) Nghia Do  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2017.06.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md9101761"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b01770"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010021\u201009783\u2010z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10886\u2010024\u201001483\u20100"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00343\u2010016\u20104334\u20108"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02977361"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.06.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.05.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1548451"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578\u00d7221105369"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578\u00d7211053934"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/md21060345"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13031202"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.118"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201026133\u20107"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c00878"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2020.107402"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.29.1942"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.29.1951"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101185381"},{"key":"e_1_2_9_23_1","volume-title":"Stereochemistry of Organic Compounds","author":"Eliel E. 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