{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:42:22Z","timestamp":1792586542567,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Safe and functional natural active ingredients are a research hotspot in early intervention studies of chronic diseases. This study focuses on a polysaccharide (CGPs\u20111) from sword bean (\n                    <jats:italic>Canavalia gladiata<\/jats:italic>\n                    (Jacq.) DC.) pods. Its optimal ultrasound\u2010assisted extraction conditions were achieved with choline chloride\/oxalic acid DES (2:1), 34% water, 21\u00a0mL\/g, 65\u00b0C, 29\u00a0min at 280\u00a0W; the actual yield (33.24%) was consistent with the predicted value (33.96%). CGPs\u20111 was identified as a pyran\u2011type polysaccharide, comprising rhamnose (Rha), glucuronic acid (GlcA), and galacturonic acid (GalA) in a molar ratio of 1.08:1:1.78. CGPs\u20111 had IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 0.157\u00a0mg\/mL (\u03b1\u2011glucosidase), 0.083\u00a0mg\/mL (\u03b1\u2011amylase), 31.18\u00a0mg\/mL (DPPH radicals), and 2.264\u00a0mg\/mL (ABTS radicals), inhibited LPS\u2011triggered inflammatory response and LPS\u2011mediated neurotoxicity in BV2 cells, and also suppressed MPTP\u2010induced inflammatory response in zebrafish larvae. Results indicate that CGPs\u20111 exhibits antioxidant, hypoglycemic, anti\u2011neuroinflammatory and neuroprotective potentials, providing preliminary experimental support for further research and the development of functional\u2011food\u2011related products derived from sword bean pods.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71766","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:59:00Z","timestamp":1792583940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Response Surface Optimization of Ultrasound\u2010Assisted Deep Eutectic Solvent Extraction of Bioactive Polysaccharides From Sword Bean (\n                    <i>Canavalia gladiata<\/i>\n                    (Jacq.) DC.) Pods"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9405-7847","authenticated-orcid":false,"given":"Jieyu","family":"Xing","sequence":"first","affiliation":[{"name":"School of Pharmacy Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4204-153X","authenticated-orcid":false,"given":"Zhaoxuan","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine Foshan University  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-9068","authenticated-orcid":false,"given":"Haiyun","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neurology Shenzhen Bao'an District Songgang People's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1701406"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010025\u201001700\u2010z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010026\u201001691\u20100"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26094209"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.08.075"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1299117"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crfs.2022.08.016"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.53388\/TMR20210916244"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196317"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X19500800"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14142853"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000000655"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032108"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15204372"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2018.00039"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750\u20103841.14057"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8070200"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068\u2010020\u201000794\u20108"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070767"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.11.096"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826068.2024.2441914"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2026.107797"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.120602"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2023.102909"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2022.116798"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.139061"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.130907"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scp.2023.101168"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.912014"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13020278"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.141469","article-title":"Pioneering Polysaccharide Extraction With Deep Eutectic Solvents: A Review on Impacts to Extraction Yield, Physicochemical Properties and Bioactivities","volume":"306","author":"Md Yusoff M. 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