{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:12Z","timestamp":1790546172254,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study,\n                    <jats:italic>Cinnamomum cassia<\/jats:italic>\n                    bark essential oil (CEO) was extracted with a yield of 2.51% and characterised by its organoleptic properties, physicochemical characteristics, and gas chromatography\u2013mass spectrometry (GC\u2013MS) profiling. Seven phytoconstituents were identified, with (E)\u2010cinnamaldehyde predominating (87.14%). CEO inhibited\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ATCC 25923\n                    <jats:italic>, Bacillus subtilis<\/jats:italic>\n                    ATCC 6633,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ATCC 25922, and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    ATCC 27853, with inhibition zones of 16.0\u00a0\u00b1\u00a01.0\u201347.0\u00a0\u00b1\u00a01.0\u00a0mm. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values ranged from 0.52\u20131.04 and 0.52\u20132.08\u00a0mg\/mL, respectively, with greater susceptibility observed among the gram\u2010positive strains. Antifungal evaluation revealed potent activity against\n                    <jats:italic>Alternaria alternata<\/jats:italic>\n                    and moderate activity against\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    , with direct\u2010contact exposure showing greater inhibition of\n                    <jats:italic>As. niger<\/jats:italic>\n                    than vapour\u2010phase treatment. Molecular docking identified coumarin, a minor constituent, as exhibiting the strongest predicted binding, with binding energies of \u22127.7\u00a0kcal\/mol against the bacterial targets TEM\u20101 \u03b2\u2010lactamase and D\u2010alanine:D\u2010alanine ligase, and \u22127.0\u00a0kcal\/mol against tyrosyl\u2010tRNA synthetase. Coumarin also showed favorable predicted binding to the fungal targets cytochrome P450 51B (CYP51B) and epoxide hydrolase. These findings support the potential of CEO as a natural antimicrobial preservative, although further validation in real food systems is required.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71767","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:46:52Z","timestamp":1790538412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antimicrobial Activity of\n                    <i>Cinnamomum cassia<\/i>\n                    Essential Oil: Phytochemical Profiling, In Vitro Evaluation, and Molecular Docking"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-3760","authenticated-orcid":false,"given":"Asma","family":"Bouguerra","sequence":"first","affiliation":[{"name":"Laboratory of Applied Microbiology, Faculty of Natural and Life Sciences Ferhat Abbas Setif 1 University  Setif Algeria"},{"name":"Department of Biology, Faculty of Natural and Life Sciences \/ Earth and Universe Sciences Mohamed El Bachir El Ibrahimi University  Bordj Bou Arreridj Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Meziti","sequence":"additional","affiliation":[{"name":"Laboratory of Health and Environment, Faculty of Natural and Life Sciences \/ Earth and Universe Sciences Mohamed El Bachir El Ibrahimi University  Bordj Bou Arreridj Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-5604","authenticated-orcid":false,"given":"Hassina","family":"Guergour","sequence":"additional","affiliation":[{"name":"Laboratory of Health and Environment, Faculty of Natural and Life Sciences \/ Earth and Universe Sciences Mohamed El Bachir El Ibrahimi University  Bordj Bou Arreridj Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8474-117X","authenticated-orcid":false,"given":"Naouel","family":"Boussoualim","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry, Department of Microbiology, Faculty of Nature and Life Sciences University Ferhat Abbas Setif 1  Setif Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Krache","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry, Department of Biochemistry, Faculty of Nature and Life Sciences University Ferhat Abbas Setif 1  Setif Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1317-7211","authenticated-orcid":false,"given":"Nadira","family":"Oukala","sequence":"additional","affiliation":[{"name":"Laboratory For the Valorization and Conservation of Biological Resources, Department of Biology M'hamed Bougara University  Boumerdes Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Saidi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Natural and Life Sciences \/ Earth and Universe Sciences Mohamed El Bachir El Ibrahimi University  Bordj Bou Arreridj Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoud","family":"Harzallah","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Microbiology, Faculty of Natural and Life Sciences Ferhat Abbas Setif 1 University  Setif Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4155-9479","authenticated-orcid":false,"given":"Shakilur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5980-391X","authenticated-orcid":false,"given":"Hamdi","family":"Bendif","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5410-7936","authenticated-orcid":false,"given":"Gharieb S.","family":"El\u2010Sayyad","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug Sapienza University P. 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