{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:29Z","timestamp":1790546189951,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005880","name":"National Institute of Biological Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Duchesnea chrysantha<\/jats:italic>\n                    (Zoll. &amp; Moritzi) Miq. (Rosaceae) has traditionally been used in East Asian medicine for inflammatory and skin\u2010related disorders. This study investigated the phytochemical composition and protective effects of\n                    <jats:italic>D. chrysantha<\/jats:italic>\n                    ethanol extract (Dc\u2010EE) against ultraviolet B (UVB)\u2010induced skin damage. Untargeted LC\u2013MS\/MS analysis tentatively annotated various phytochemical constituents, including flavonoids and phenolic acids. Dc\u2010EE reduced UVB\u2010induced oxidative stress, reactive oxygen species production, and apoptosis in human keratinocytes (HaCaT) and dermal fibroblasts (HDF). It also suppressed cyclooxygenase\u20102 and matrix metalloproteinases (MMP\u20101, MMP\u20102, and MMP\u20109) in HaCaT cells while restoring collagen type I alpha 1 expression in HDF cells. In addition, Dc\u2010EE enhanced the expression of skin barrier\u2010 and hydration\u2010related factors, including filaggrin, transglutaminase\u20101, and hyaluronan synthase\u20102. Dc\u2010EE attenuated UVB\u2010induced MAPK signaling by reducing JNK, ERK, and p38 phosphorylation, together with AP\u20101 and NF\u2010\u03baB transcriptional activities. Reduced activation of transforming growth factor\u2010\u03b2\u2010activated kinase 1, an upstream stress\u2010responsive regulator, was also observed. These findings indicate that Dc\u2010EE attenuates UVB\u2010induced cellular damage through antioxidant, anti\u2010inflammatory, and barrier\u2010related effects, supporting its potential for skin protection.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71768","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:54:06Z","timestamp":1790538846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of\n                    <i>Duchesnea chrysantha<\/i>\n                    Ethanol Extract Against UVB\u2010Induced Skin Damage via Modulation of TAK1\u2010Associated Signaling Pathways"],"prefix":"10.1002","volume":"23","author":[{"given":"Yerkyesh","family":"Khamit","sequence":"first","affiliation":[{"name":"Department of Biocosmetics Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biocosmetics Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6210-9001","authenticated-orcid":false,"given":"Jinghan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilda","family":"Kaskadamova","sequence":"additional","affiliation":[{"name":"Department of Integrative Biotechnology Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Segon","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Biocosmetics Sungkyunkwan University  Suwon Republic of Korea"},{"name":"Hanmi Cosmetic Inc.  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